Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

Programmed cell death (PCD), referring to apoptosis, autophagy and programmed necrosis,
is proposed to be death of a cell in any pathological format, when mediated by an …

Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

Reactive oxygen species (ROS) are products of normal metabolism and xenobiotic
exposure, and depending on their concentration, ROS can be beneficial or harmful to cells …

Significance: Protein S-nitrosylation, the oxidative modification of cysteine by nitric oxide
(NO) to form protein S-nitrosothiols (SNOs), mediates redox-based signaling that conveys, in …

During the past two decades, nitric oxide (NO) has been recognized as one of the most
versatile players in the immune system. It is involved in the pathogenesis and control of …

Myeloid-derived suppressor cells (MDSCs) are one of the main cell populations responsible
for regulating immune responses. MDSCs accumulate during tumor progression …

Reactive oxygen species (ROS) are generated as by-products of aerobic respiration and
metabolism. Mammalian cells have evolved a variety of enzymatic mechanisms to control …

Abstract Changes in redox status are a conspicuous feature of immune responses in a
variety of eukaryotes,, but the associated signalling mechanisms are not well understood. In …

We summarize here results of studies designed to elucidate basic mechanisms of reactive
oxygen (ROS)-mediated oxidation of proteins and free amino acids. These studies have …