Insulin, insulin-like growth factors (IGFs) and insulin-like peptides (ILPs) are important
regulators of metabolism, growth, reproduction and lifespan, and mechanisms of insulin/IGF …

A remarkable discovery of recent years is that, despite the complexity of ageing, simple
genetic interventions can increase lifespan and improve health during ageing in laboratory …

Regenerative processes are critical to maintain tissue homeostasis in high-turnover tissues.
At the same time, proliferation of stem and progenitor cells has to be carefully controlled to …

Adaptation of organisms to ever-changing nutritional environments relies on sensor tissues
and systemic signals. Identification of these signals would help understand the physiological …

Insulin-like peptides (ILPs) and growth factors (IGFs) not only regulate development, growth,
reproduction, metabolism, stress resistance, and lifespan, but also certain behaviors and …

Taking advantage of Drosophila as a genetically tractable experimental animal much
progress has been made in our understanding of how the insulin/IGF signaling (IIS) pathway …

Drosophila melanogaster represents one of the most important genetically accessible model
organisms for aging research. Studies in flies have identified single gene mutations that …

Insulin‐like peptides (ILPs) belong to the insulin superfamily and act as hormones,
neuromediators, and growth factors during the post‐embryonic life‐cycle stages of insects …

Gene expression changes in response to aging, heat stress, hyperoxia, hydrogen peroxide,
and ionizing radiation were compared using microarrays. A set of 18 genes were up …

Insulin/IGF-like signaling regulates the development, growth, fecundity, metabolic
homeostasis, stress resistance and lifespan in worms, flies and mammals. Eight insulin-like …