Multiplex protein imaging in tumour biology

N de Souza, S Zhao, B Bodenmiller - Nature Reviews Cancer, 2024 - nature.com
Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …

Highly Multiplexed Tissue Imaging in Precision Oncology and Translational Cancer Research

A Bollhagen, B Bodenmiller - Cancer Discovery, 2024 - aacrjournals.org
Precision oncology tailors treatment strategies to a patient's molecular and health data.
Despite the essential clinical value of current diagnostic methods, hematoxylin and eosin …

DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging

T Hosogane, R Casanova, B Bodenmiller - Nature Methods, 2023 - nature.com
Imaging mass cytometry (IMC) is a highly multiplexed, antibody-based imaging method that
captures heterogeneous spatial protein expression patterns at subcellular resolution. Here …

Highly multiplexed imaging in the omics era: understanding tissue structures in health and disease

B Bodenmiller - nature methods, 2024 - nature.com
Spatial proteomics is advancing rapidly, transforming physiological and biomedical research
by enabling the study of how multicellular structures and intercellular communication shape …

Mutation-Selected Amplification droplet digital PCR: A new single nucleotide variant detection assay for TP53R249S mutant in tumor and plasma samples

L Hu, YY Ji, P Zhu, RQ Lu - Analytica Chimica Acta, 2024 - Elsevier
The early detection of gene mutations in physiological and pathological processes is a
powerful approach to guide decisions in precision medicine. However, detecting low-copy …

Integrated Multifunctional Platform with X-ray and Near-Infrared Driven Photochromic Behavior for Reversible Quad-Mode Optical Imaging

R Kuang, H Lian, M Gao, Y Zhu, S Gu, L Shen… - ACS Materials …, 2025 - ACS Publications
Noninvasive optical imaging techniques, including X-ray and near-infrared (NIR), hold
significant value for scientific research and industrial applications. However, there is still a …

Clickable X-ray Nanoprobes for Nanoscopic Bioimaging of Cellular Structures

Q Tang, D Yin, Y Liu, J Zhang, Y Guan, H Kong… - JACS Au, 2024 - ACS Publications
Synchrotron-based X-ray microscopy (XRM) has garnered widespread attention from
researchers due to its high spatial resolution and excellent energy (element) resolution …

[HTML][HTML] Label-free spatiotemporal decoding of single-cell fate via acoustic driven 3D tomography

Y Wang, S Zhou, Y Quan, Y Liu, B Zhou, X Chen… - Materials Today Bio, 2024 - Elsevier
Label-free three-dimensional imaging plays a crucial role in unraveling the complexities of
cellular functions and interactions in biomedical research. Conventional single-cell optical …

Synchrotron-based correlative imaging of metals and proteins in neuronal cells: state of the art and future challenges in neurometallomics

I Kelkoul, VP Muñoz, R Ortega, A Carmona - Metallomics, 2025 - academic.oup.com
Metal homeostasis in the nervous system is subtly regulated and changes in metal
distribution or content, either increases or decreases, are associated with …

[HTML][HTML] Iodinated PSMA Ligands as XFI Tracers for Targeted Cell Imaging and Characterization of Nanoparticles

S Kerpa, M Holzapfel, T Staufer, R Kuhrwahl… - International Journal of …, 2024 - mdpi.com
Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Despite
this, current diagnostic tools are still not satisfactory, lacking sensitivity for early-stage or …