Insights from genomic profiling of transcription factors
PJ Farnham - Nature Reviews Genetics, 2009 - nature.com
A crucial question in the field of gene regulation is whether the location at which a
transcription factor binds influences its effectiveness or the mechanism by which it regulates …
transcription factor binds influences its effectiveness or the mechanism by which it regulates …
Regulation of plant secondary metabolism and associated specialized cell development by MYBs and bHLHs
WR Chezem, NK Clay - Phytochemistry, 2016 - Elsevier
Plants are unrivaled in the natural world in both the number and complexity of secondary
metabolites they produce, and the ubiquitous phenylpropanoids and the lineage-specific …
metabolites they produce, and the ubiquitous phenylpropanoids and the lineage-specific …
ChIP-seq: using high-throughput sequencing to discover protein–DNA interactions
Chromatin immunoprecipitation (ChIP) allows specific protein–DNA interactions to be
isolated. Combining ChIP with high-throughput sequencing reveals the DNA sequence …
isolated. Combining ChIP with high-throughput sequencing reveals the DNA sequence …
ATR protects the genome against R loops through a MUS81-triggered feedback loop
R loops arising during transcription induce genomic instability, but how cells respond to the
R loop-associated genomic stress is still poorly understood. Here, we show that cells …
R loop-associated genomic stress is still poorly understood. Here, we show that cells …
The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression
Retinoblastoma (RB; encoded by RB1) is a tumor suppressor that is frequently disrupted in
tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of …
tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of …
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
M Benhamed, U Herbig, T Ye, A Dejean, O Bischof - Nature cell biology, 2012 - nature.com
Cellular senescence is a tumour-suppressor mechanism that is triggered by cancer-initiating
or promoting events in mammalian cells. The molecular underpinnings for this stable arrest …
or promoting events in mammalian cells. The molecular underpinnings for this stable arrest …
Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia
JA Pulikkan, V Dengler… - Blood, The Journal …, 2010 - ashpublications.org
Transcription factor CCAAT enhancer binding protein α (C/EBPα) is essential for
granulopoiesis and its function is deregulated in leukemia. Inhibition of E2F1, the master …
granulopoiesis and its function is deregulated in leukemia. Inhibition of E2F1, the master …
Transcription factors: specific DNA binding and specific gene regulation
Specific recognition of cis-regulatory regions is essential for correct gene regulation in
response to developmental and environmental signals. Such DNA sequences are …
response to developmental and environmental signals. Such DNA sequences are …
Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers
Clustering of multiple transcription factor binding sites (TFBSs) for the same transcription
factor (TF) is a common feature of cis-regulatory modules in invertebrate animals, but the …
factor (TF) is a common feature of cis-regulatory modules in invertebrate animals, but the …
RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation
Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for
which no specific treatment is currently available. Although the retinoblastoma tumor …
which no specific treatment is currently available. Although the retinoblastoma tumor …