Biomarkers for C9orf7-ALS in Symptomatic and Pre-symptomatic Patients: State-of-the-art in the New Era of Clinical Trials
G Querin, MG Biferi, PF Pradat - Journal of neuromuscular …, 2022 - content.iospress.com
The development of new possible treatments for C9orf72-related ALS and the possibility of
early identification of subjects genetically at risk of developing the disease is creating a …
early identification of subjects genetically at risk of developing the disease is creating a …
Brain connectivity and network analysis in amyotrophic lateral sclerosis
V Renga - Neurology Research International, 2022 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no effective
treatment or cure. ALS is characterized by the death of lower motor neurons (LMNs) in the …
treatment or cure. ALS is characterized by the death of lower motor neurons (LMNs) in the …
Amyotrophic lateral sclerosis–frontotemporal dementia: Shared and divergent neural correlates across the clinical spectrum
C Cividini, S Basaia, EG Spinelli, E Canu… - Neurology, 2022 - AAN Enterprises
Background and Objectives A significant overlap between amyotrophic lateral sclerosis
(ALS) and behavioral variant of frontotemporal dementia (bvFTD) has been observed at …
(ALS) and behavioral variant of frontotemporal dementia (bvFTD) has been observed at …
[HTML][HTML] C9orf72 ALS mutation carriers show extensive cortical and subcortical damage compared to matched wild-type ALS patients
Objective C9orf72 mutation carriers with different neurological phenotypes show cortical and
subcortical atrophy in multiple different brain regions, even in pre-symptomatic phases …
subcortical atrophy in multiple different brain regions, even in pre-symptomatic phases …
Multiparametric microstructural MRI and machine learning classification yields high diagnostic accuracy in amyotrophic lateral sclerosis: proof of concept
The potential of multiparametric quantitative neuroimaging has been extensively discussed
as a diagnostic tool in amyotrophic lateral sclerosis (ALS). In the past, the integration of …
as a diagnostic tool in amyotrophic lateral sclerosis (ALS). In the past, the integration of …
[HTML][HTML] Segmental alterations of the corpus callosum in motor neuron disease: A DTI and texture analysis in 575 patients
Introduction Within the core neuroimaging signature of amyotrophic lateral sclerosis (ALS),
the corpus callosum (CC) is increasingly recognized as a consistent feature. The aim of this …
the corpus callosum (CC) is increasingly recognized as a consistent feature. The aim of this …
Evaluation and categorisation of individual patients based on white matter profiles: Single-patient diffusion data interpretation in neurodegeneration
M Tahedl, A Murad, J Lope, O Hardiman… - Journal of the neurological …, 2021 - Elsevier
The majority of radiology studies in neurodegenerative conditions infer group-level imaging
traits from group comparisons. While this strategy is helpful to define phenotype-specific …
traits from group comparisons. While this strategy is helpful to define phenotype-specific …
Longitudinal monitoring of amyotrophic lateral sclerosis by diffusion tensor imaging: Power calculations for group studies
A Behler, D Lulé, AC Ludolph, J Kassubek… - Frontiers in …, 2022 - frontiersin.org
Introduction Diffusion tensor imaging (DTI) can be used to map disease progression in
amyotrophic lateral sclerosis (ALS) and therefore is a promising candidate for a biomarker in …
amyotrophic lateral sclerosis (ALS) and therefore is a promising candidate for a biomarker in …
The ipsilateral silent period: an early diagnostic marker of callosal disconnection in ALS
A Hübers, J Kassubek, HP Müller… - … in Chronic Disease, 2021 - journals.sagepub.com
Introduction: Imaging studies showed affection of the corpus callosum (CC) in amyotrophic
lateral sclerosis (ALS). Here, we sought to determine whether these structural alterations …
lateral sclerosis (ALS). Here, we sought to determine whether these structural alterations …
[HTML][HTML] Temporal and spatial progression of microstructural cerebral degeneration in ALS: A multicentre longitudinal diffusion tensor imaging study
Objective The corticospinal tract (CST) reveals progressive microstructural alterations in ALS
measurable by DTI. The aim of this study was to evaluate fractional anisotropy (FA) along …
measurable by DTI. The aim of this study was to evaluate fractional anisotropy (FA) along …