Production of minute concentrations of superoxide (O 2 radical dot−) and nitrogen monoxide
(nitric oxide, NO radical dot) plays important roles in several aspects of cellular signaling …

Iron is an essential nutrient with limited bioavailability. When present in excess, iron poses a
threat to cells and tissues, and therefore iron homeostasis has to be tightly controlled. Iron's …

Both, mammalian cells and microbes have an essential need for iron, which is required for
many metabolic processes and for microbial pathogenicity. In addition, cross-regulatory …

As an essential nutrient and a potential toxin, iron poses an exquisite regulatory problem in
biology and medicine. At the cellular level, the basic molecular framework for the regulation …

The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to
mediate cellular uptake of iron from a plasma glycoprotein, transferrin. Iron uptake from …

Macrophages reside in virtually every organ. First arising during embryogenesis,
macrophages replenish themselves in the adult through a combination of self-renewal and …

Iron and oxygen share a delicate partnership since both are indispensable for survival, but if
the partnership becomes inadequate, this may rapidly terminate life. Virtually all cell …

▪ Abstract Mammalian iron homeostasis is maintained through the concerted action of
sensory and regulatory networks that modulate the expression of proteins of iron metabolism …

Cellular iron homeostasis is accomplished by the coordinated regulated expression of the
transferrin receptor and ferritin, which mediate iron uptake and storage, respectively. The …

Since transferrin was discovered more than half a century ago, a considerable effort has
been made towards understanding tranferrin‐mediated iron uptake. However, it was not …