A major feature of Alzheimer's disease (AD) pathology is the plaque composed of
aggregated amyloid-β (Aβ) peptide. Although these plaques may have harmful properties …

Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

While a massive and progressive neuronal loss in specific areas such as the hippocampus
and cortex unequivocally underlies cognitive deterioration and memory loss in Alzheimer's …

Prion protein (PrP) protects neural cells against oxidative stress, hypoxia, ischemia, and
hypoglycemia. In the present study we confirm that cultured PrP‐deficient neurons are more …

Recent studies strongly indicate that aberrations in the control of gene expression might
contribute to the initiation and progression of Alzheimer's disease (AD). In particular …

Alternative pre-mRNA splicing has an important role in the control of neuronal gene
expression. Many neuronal proteins are structurally diversified through the differential …

Although Aβ peptides are causative agents in Alzheimer's disease (AD), the underlying
mechanisms are still elusive. We report that Aβ42 induces a translational block by activating …

The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …

The E4 allele of the ApoE gene has consistently been shown to be related to an increased
risk of Alzheimer's disease (AD). The E4 allele is also associated with functional and …