Ex-vivo Kidney Machine Perfusion: Therapeutic Potential

R Zulpaite, P Miknevicius, B Leber, K Strupas… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

[HTML][HTML] Renal normothermic machine perfusion: the road toward clinical implementation of a promising pretransplant organ assessment tool

TL Hamelink, B Ogurlu, J De Beule, VA Lantinga… - …, 2022 - journals.lww.com
The increased utilization of high-risk renal grafts for transplantation requires optimization of
pretransplant organ assessment strategies. Current decision-making methods to accept an …

Renal delivery of pharmacologic agents during machine perfusion to prevent ischaemia-reperfusion injury: from murine model to clinical trials

R Franzin, A Stasi, M Fiorentino, S Simone… - Frontiers in …, 2021 - frontiersin.org
Donor organ shortage still remains a serious obstacle for the access of wait-list patients to
kidney transplantation, the best treatment for End-Stage Kidney Disease (ESKD). To expand …

[HTML][HTML] Urine recirculation prolongs normothermic kidney perfusion via more optimal metabolic homeostasis—a proteomics study

A Weissenbacher, H Huang, T Surik, MLL Faro… - American Journal of …, 2021 - Elsevier
We describe a proteomics analysis to determine the molecular differences between
normothermically perfused (normothermic machine perfusion, NMP) human kidneys with …

A cell-free nutrient-supplemented perfusate allows four-day ex vivo metabolic preservation of human kidneys

MJA de Haan, ME Jacobs, FMR Witjas… - Nature …, 2024 - nature.com
The growing disparity between the demand for transplants and the available donor supply,
coupled with an aging donor population and increasing prevalence of chronic diseases …

[HTML][HTML] Perfusate Composition and Duration of Ex-Vivo Normothermic Perfusion in Kidney Transplantation: A Systematic Review

A Fard, R Pearson, R Lathan… - Transplant …, 2022 - frontierspartnerships.org
Ex-vivo normothermic perfusion (EVNP) is an emerging strategy in kidney preservation that
enables resuscitation and viability assessment under pseudo-physiological conditions prior …

Normothermic machine perfusion of kidneys: current strategies and future perspectives

F Messner, C Bogensperger, JP Hunter… - Current opinion in …, 2022 - journals.lww.com
Normothermic machine perfusion of kidneys: current strategie... : Current Opinion in Organ
Transplantation Normothermic machine perfusion of kidneys: current strategies and future …

A comparison of pulsatile hypothermic and normothermic ex vivo machine perfusion in a porcine kidney model

N Vallant, N Wolfhagen, B Sandhu, K Hamaoui… - …, 2021 - journals.lww.com
Background. Hypothermic machine perfusion (HMP) is a well-established method for
deceased donor kidney preservation. Normothermic machine perfusion (NMP) might offer …

[HTML][HTML] 48 h normothermic machine perfusion with urine recirculation for discarded human kidney grafts

F Messner, A Soleiman, D Öfner… - Transplant …, 2023 - frontierspartnerships.org
Background: Normothermic machine perfusion (NMP) has reshaped organ preservation in
recent years. In this preclinical study, prolonged normothermic perfusions of discarded …

Hemodynamics and metabolic parameters in normothermic kidney preservation are linked with donor factors, perfusate cells, and cytokines

A Weissenbacher, JP Stone, ML Lo Faro… - Frontiers in …, 2022 - frontiersin.org
Kidney transplantation is the best renal-replacement option for most patients with end-stage
renal disease. Normothermic machine preservation (NMP) of the kidney has been studied …