Emergence of extracellular vesicles as “liquid biopsy” for neurological disorders: boom or bust

A Kumar, MA Nader, G Deep, A Baker - Pharmacological reviews, 2024 - Elsevier
Extracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the
diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching …

Plasma versus serum for extracellular vesicle (EV) isolation: A duel for reproducibility and accuracy for CNS‐originating EVs biomarker analysis

HB Taha - Journal of Neuroscience Research, 2023 - Wiley Online Library
Blood‐derived extracellular vesicles (EVs) are a popular source of biomarkers for central
nervous system (CNS) diseases, but inconsistencies in isolation and analysis hinder their …

Measurement of α-synuclein as protein cargo in plasma extracellular vesicles

T Gilboa, D Ter-Ovanesyan, SC Wang… - Proceedings of the …, 2024 - pnas.org
Extracellular vesicles (EVs) are released by all cells and hold great promise as a class of
biomarkers. This promise has led to increased interest in measuring EV proteins from both …

Evaluation of α‐synuclein in CNS‐originating extracellular vesicles for parkinsonian disorders: a systematic review and meta‐analysis

HB Taha, SS Ati - CNS Neuroscience & Therapeutics, 2023 - Wiley Online Library
Abstract Background & Aims Parkinsonian disorders, such as Parkinson's disease (PD),
multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear …

Analysis of biomarkers in speculative CNS-enriched extracellular vesicles for parkinsonian disorders: a comprehensive systematic review and diagnostic meta …

HB Taha, A Bogoniewski - Journal of Neurology, 2024 - Springer
Background and objective Parkinsonian disorders, including Parkinson's disease (PD),
multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear …

Proteomic analysis of plasma-derived extracellular vesicles: Pre-and postprandial comparisons

AP Garza, E Wider-Eberspächer, L Morton… - Scientific Reports, 2024 - nature.com
Extracellular vesicles (EVs) are key in intercellular communication, carrying biomolecules
like nucleic acids, lipids, and proteins. This study investigated postprandial characteristics …

The role of exosomes in the diagnosis of Parkinson's disease

Q Shi, W Kang, Z Liu, X Zhu - Heliyon, 2023 - cell.com
Parkinson's disease is a common neurodegenerative disease characterized by intracellular
aggregation of misfolded α-synuclein as a major pathological hallmark. Exosomes are cell …

[HTML][HTML] Comparative Analysis of Exosomes and Extracellular Microvesicles in Healing Pathways: Insights for Advancing Regenerative Therapies

M Sędzik, K Rakoczy, J Sleziak, M Kisiel, K Kraska… - Molecules, 2024 - mdpi.com
Exosomes and microvesicles bear great potential to broaden therapeutic options in the
clinical context. They differ in genesis, size, cargo, and composition despite their similarities …

CX3CR1+/UCHL1+ microglial extracellular vesicles in blood: a potential biomarker for multiple sclerosis

J Duan, A Lv, Z Guo, Q Liu, C Tian, Y Yang, J Bi… - Journal of …, 2024 - Springer
In neuroinflammation, distinguishing microglia from macrophages and identifying microglial-
specific biomarkers in peripheral blood pose significant challenges. This study …

Extracellular vesicles from bodily fluids for the accurate diagnosis of Parkinson's disease and related disorders: A systematic review and diagnostic meta‐analysis

HB Taha, A Bogoniewski - Journal of Extracellular Biology, 2023 - Wiley Online Library
Parkinsonian disorders, including Parkinson's disease (PD), multiple system atrophy (MSA),
dementia with Lewy body (DLB), corticobasal syndrome (CBS) and progressive …