The immunobiology of interleukin-27
H Yoshida, CA Hunter - Annual review of immunology, 2015 - annualreviews.org
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …
response. Although it was initially linked with the development of Th1 responses, it is now …
Interleukin-27: balancing protective and pathological immunity
CA Hunter, R Kastelein - Immunity, 2012 - cell.com
It has been more than 15 years since the identification of individual interleukin-27 (IL-27)
and IL-27 receptor components. The last decade has seen the description of the signaling …
and IL-27 receptor components. The last decade has seen the description of the signaling …
gp130 at the nexus of inflammation, autoimmunity, and cancer
Review highlights the function of the cytokine receptor gp130, specifically the diverse roles it
plays in inflammation, autoimmunity, and cancer. Glycoprotein 130 (gp130) is a shared …
plays in inflammation, autoimmunity, and cancer. Glycoprotein 130 (gp130) is a shared …
IL-27-induced modulation of autoimmunity and its therapeutic potential
Abstract Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by
activated antigen-presenting cells and plays an important role in the regulation of CD4+ T …
activated antigen-presenting cells and plays an important role in the regulation of CD4+ T …
Genome instability in multiple myeloma: Facts and factors
Simple Summary Multiple myeloma is an incurable blood cancer caused by the malignant
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …
transformation of immunoglobulin-producing plasma cells. The mechanisms leading to the …
Regulation of immune responses by interleukin‐27
H Yoshida, M Yoshiyuki - Immunological reviews, 2008 - Wiley Online Library
Cytokine‐mediated immunity plays a crucial role in the pathogenesis of various diseases
including autoimmunity. Recently, interleukin‐27 (IL‐27) was identified, which, along with IL …
including autoimmunity. Recently, interleukin‐27 (IL‐27) was identified, which, along with IL …
New directions in the basic and translational biology of interleukin-27
Interleukin (IL)-27 is a member of the IL-6 and IL-12 family composed of the IL-27p28 and
Epstein–Barr virus-induced gene 3 (EBI3) subunits. Although IL-27 was originally identified …
Epstein–Barr virus-induced gene 3 (EBI3) subunits. Although IL-27 was originally identified …
Interleukin-27 and its diverse effects on bacterial infections
Y Morita, EA Masters, EM Schwarz… - Frontiers in …, 2021 - frontiersin.org
Innate and adaptive immune responses against pathogens are known to be carefully
orchestrated by specific cytokines that initiate and down regulate immune cell functions from …
orchestrated by specific cytokines that initiate and down regulate immune cell functions from …
IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages
T Imamichi, J Yang, DW Huang, TW Brann, BA Fullmer… - Aids, 2008 - journals.lww.com
Objective: IL-27 is a novel anti-HIV cytokine that inhibits HIV-1 replication in both CD4 T cells
and monocyte-derived macrophages (MDM) as IFN-α does. To elucidate the mechanism of …
and monocyte-derived macrophages (MDM) as IFN-α does. To elucidate the mechanism of …