The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Congenital PAX6-aniridia, initially characterized by the absence of the iris, has progressively
been shown to be associated with other developmental ocular abnormalities and systemic …

Pax6 is a highly conserved transcription factor among vertebrates and is important in various
developmental processes in the central nervous system (CNS), including patterning of the …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Understanding brain development remains a major challenge at the heart of understanding
what makes us human. The neocortex, in evolutionary terms the newest part of the cerebral …

Populations of self-renewing cells that arise during normal embryonic development harbour
the potential for rapid proliferation, migration or transdifferentiation and, therefore, tumour …

Multipotent retinal progenitors undergo a varied number of divisions to produce clones of
heterogeneous sizes and cell types. We describe the transition from a proliferating …

Many cerebral cortical neurons and glia are produced by apical progenitors dividing at the
ventricular surface of the embryonic dorsal telencephalon. Other neurons are produced by …

Diseases that result in retinal pigment epithelium (RPE) degeneration, such as age-related
macular degeneration (AMD), are among the leading causes of blindness worldwide …

The vertebrate eye is composed of both surface ectodermal and neuroectodermal
derivatives that evaginate laterally from an epithelial anlage of the forming diencephalon …