Diving into the complexity of the spirochetal endoflagellum

F San Martin, L Fule, G Iraola, A Buschiazzo… - Trends in …, 2023 - cell.com
Spirochaetes, a phylum that includes medically important pathogens such as the causative
agents of Lyme disease, syphilis, and leptospirosis, are in many ways highly unique …

[HTML][HTML] Structure and dynamics of the bacterial flagellar motor complex

S Nakamura, T Minamino - Biomolecules, 2024 - mdpi.com
Many bacteria swim in liquids and move over solid surfaces by rotating flagella. The
bacterial flagellum is a supramolecular protein complex that is composed of about 30 …

Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit

H Hu, PF Popp, M Santiveri, A Roa-Eguiara… - Nature …, 2023 - nature.com
Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly
motile bacteria responsible for various human diseases, the polar flagella of which are …

A multi-state dynamic process confers mechano-adaptation to a biological nanomachine

N Wadhwa, A Sassi, HC Berg, Y Tu - Nature Communications, 2022 - nature.com
Adaptation is a defining feature of living systems. The bacterial flagellar motor adapts to
changes in the external mechanical load by adding or removing torque-generating (stator) …

Flagellar protein FliL: A many‐splendored thing

JD Partridge, RM Harshey - Molecular Microbiology, 2024 - Wiley Online Library
FliL is a bacterial flagellar protein demonstrated to associate with, and regulate ion flow
through, the stator complex in a diverse array of bacterial species. FliL is also implicated in …

PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa

S Guo, Y Chang, YV Brun, PL Howell… - Nature …, 2024 - nature.com
Abstract Type IV pili (T4P) produced by the pathogen Pseudomonas aeruginosa play a
pivotal role in adhesion, surface motility, biofilm formation, and infection in humans. Despite …

Recent technical advances in cellular cryo-electron tomography

T Zheng, S Cai - The International Journal of Biochemistry & Cell …, 2024 - Elsevier
Understanding the in situ structure, organization, and interactions of macromolecules is
essential for elucidating their functions and mechanisms of action. Cellular cryo-electron …

FliL and its paralog MotF have distinct roles in the stator activity of the Sinorhizobium meliloti flagellar motor

RC Sobe, C Gilbert, L Vo, G Alexandre… - Molecular …, 2022 - Wiley Online Library
The bacterial flagellum is a complex macromolecular machine that drives bacteria through
diverse fluid environments. Although many components of the flagellar motor are conserved …

Tetrameric PilZ protein stabilizes stator ring in complex flagellar motor and is required for motility in Campylobacter jejuni

Y Chen, S Tachiyama, Y Li, X Feng, H Zhao… - Proceedings of the …, 2025 - pnas.org
Rotation of the bacterial flagellum, the first identified biological rotary machine, is driven by
its stator units. Knowledge gained about the function of stator units has increasingly led to …

The bacterial flagellar motor: Insights into torque generation, rotational switching, and mechanosensing

S Guo, J Liu - Frontiers in Microbiology, 2022 - frontiersin.org
The flagellar motor is a bidirectional rotary nanomachine used by many bacteria to sense
and move through environments of varying complexity. The bidirectional rotation of the …