Norditerpenoid alkaloids from Aconitum and Delphinium: Structural relevance in medicine, toxicology, and metabolism

AMA Qasem, Z Zeng, MG Rowan… - Natural Product …, 2022 - pubs.rsc.org
Covering: 77 AD up to 2020 Norditerpenoid alkaloids (NDA), typically N-ethylpiperidine
containing C19 or C18 natural product diterpenes, are hexacycles with several contiguous …

Overview of the chemistry and biological activities of natural atisine-type diterpenoid alkaloids

J Zheng, H Jiang, Y Yan, T Yin - RSC advances, 2024 - pubs.rsc.org
Atisine-type C20-diterpenoid alkaloids (DAs) are a very important class of diterpenoid
alkaloids, which play an important role in the biosynthesis of DAs. To date, 87 atisine-type …

Total Synthesis of Puberuline C

T Shimakawa, S Nakamura, H Asai… - Journal of the …, 2022 - ACS Publications
Puberuline C (1) is an architecturally complex C19-diterpenoid alkaloid with a unique ring
fusion pattern. The 6/7/5/6/6/6-membered rings (ABCDEF-rings) contain one tertiary amine …

The diterpenoid alkaloids

XY Liu, BW Ke, Y Qin, FP Wang - The alkaloids: chemistry and biology, 2022 - Elsevier
The diterpenoid alkaloids are a family of extremely important natural products that have long
been a research hotspot due to their myriad of intricate structures and diverse biological …

Design, synthesis, and biological evaluation of low-toxic lappaconitine derivatives as potential analgesics

Y Li, Y Shang, X Li, Y Zhang, J Xie, L Chen… - European Journal of …, 2022 - Elsevier
The C 18-diterpenoid alkaloid lappaconitine (LA) is a non-addictive analgesic used in
China. The toxicity (LD 50= 11.7 mg/kg) limits its application. Two series of LA derivatives …

Intermediate complex morphophysiological dormancy in seeds of Aconitum barbatum (Ranunculaceae)

L Zhang, C Xu, H Liu, Q Wu, J Tao, K Zhang - BMC Plant Biology, 2023 - Springer
Background Seed dormancy and germination are key components of plant regeneration
strategies. Aconitum barbatum is a plant commonly found in northeast China. Although it has …

[HTML][HTML] Advancements in Non-Addictive Analgesic Diterpenoid Alkaloid Lappaconitine: A Review

W Zhang, S Mi, X He, J Cui, K Zhi, J Zhang - International Journal of …, 2024 - mdpi.com
The perennial herb Aconitum sinomontanum Nakai (Ranunculaceae) has been utilized as a
traditional oriental medicine in China for numerous years. The principal pharmacological …

Profiling alkaloids in Aconitum pendulum N. Busch collected from different elevations of Qinghai province using widely targeted metabolomics

JJ Wang, HY Lou, Y Liu, HP Han, FW Ma, WD Pan… - Phytochemistry, 2022 - Elsevier
Abstract Aconitum pendulum N. Busch (Ranunculaceae) is rich in alkaloids with anti-
inflammatory and analgesic activities. Many studies have focused on the identification or …

Chemical components of Aconitum barbatum var. puberulum and their cytotoxic and antibacterial activities

N Ablajan, B Zhao, X Wenjuan, J Zhao… - Natural Product …, 2023 - Taylor & Francis
Nineteen compounds, including seventeen alkaloids O-methylarmepavine (1),(S) 6
methoxy1 (4 methoxybenzyl) 2 methyl 1, 2, 3, 4 tetrahydroisoquinolin7ol (2),(+)-(IR, laR) …

Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities

X Wang, J Xin, L Sun, Y Sun, Y Xu, F Zhao, C Niu, S Liu - Molecules, 2024 - mdpi.com
Terpenoid alkaloids are recognized as a class of compounds with limited numbers but
potent biological activities, primarily derived from plants, with a minor proportion originating …