Deep learning methods for drug response prediction in cancer: predominant and emerging trends

A Partin, TS Brettin, Y Zhu, O Narykov, A Clyde… - Frontiers in …, 2023 - frontiersin.org
Cancer claims millions of lives yearly worldwide. While many therapies have been made
available in recent years, by in large cancer remains unsolved. Exploiting computational …

Compound–protein interaction prediction by deep learning: databases, descriptors and models

BX Du, Y Qin, YF Jiang, Y Xu, SM Yiu, H Yu, JY Shi - Drug discovery today, 2022 - Elsevier
The screening of compound–protein interactions (CPIs) is one of the most crucial steps in
finding hit and lead compounds. Deep learning (DL) methods for CPI prediction can address …

GADRP: graph convolutional networks and autoencoders for cancer drug response prediction

H Wang, C Dai, Y Wen, X Wang, W Liu… - Briefings in …, 2023 - academic.oup.com
Drug response prediction in cancer cell lines is of great significance in personalized
medicine. In this study, we propose GADRP, a cancer drug response prediction model …

A systematic assessment of deep learning methods for drug response prediction: from in vitro to clinical applications

B Shen, F Feng, K Li, P Lin, L Ma… - Briefings in …, 2023 - academic.oup.com
Drug response prediction is an important problem in personalized cancer therapy. Among
various newly developed models, significant improvement in prediction performance has …

Drug discovery and mechanism prediction with explainable graph neural networks

C Wang, GA Kumar, JC Rajapakse - Scientific Reports, 2025 - nature.com
Apprehension of drug action mechanism is paramount for drug response prediction and
precision medicine. The unprecedented development of machine learning and deep …

Artificial intelligence for drug response prediction in disease models

PJ Ballester, R Stevens, B Haibe-Kains… - Briefings in …, 2022 - academic.oup.com
Accumulated preclinical data are increasingly being re-used to build and validate predictive
models generated by artificial intelligence (AI)[1] algorithms. Such in silico models have a …

DBGRU-SE: predicting drug–drug interactions based on double BiGRU and squeeze-and-excitation attention mechanism

M Zhang, H Gao, X Liao, B Ning, H Gu… - Briefings in …, 2023 - academic.oup.com
The prediction of drug–drug interactions (DDIs) is essential for the development and
repositioning of new drugs. Meanwhile, they play a vital role in the fields of …

Advances in AI and machine learning for predictive medicine

A Sharma, A Lysenko, S Jia, KA Boroevich… - Journal of Human …, 2024 - nature.com
The field of omics, driven by advances in high-throughput sequencing, faces a data
explosion. This abundance of data offers unprecedented opportunities for predictive …

DeepDRA: Drug repurposing using multi-omics data integration with autoencoders

T Mohammadzadeh-Vardin, A Ghareyazi… - Plos one, 2024 - journals.plos.org
Cancer treatment has become one of the biggest challenges in the world today. Different
treatments are used against cancer; drug-based treatments have shown better results. On …

Artificial intelligence and nanotechnology for cervical cancer treatment: Current status and future perspectives

S Kour, I Biswas, S Sheoran, S Arora, P Sheela… - Journal of Drug Delivery …, 2023 - Elsevier
Cancer epigenetics has become increasingly popular due to the reversible nature of
epigenetic changes that tend to take place during carcinogenesis. Cervical tumorigenesis in …