Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in
mammals and are responsible for the regulation of most physiological functions. Besides …

In this Review, we describe the pathogenesis, diagnosis and management of primary
hyperparathyroidism (PHPT), with a focus on recent advances in the field. PHPT is a …

Hypercalcemia of malignancy is a common finding typically found in patients with advanced
stage cancers. We aimed to provide an updated review on the etiology, pathogenesis …

Principles of Bone Biology provides the most comprehensive, authoritative reference on the
study of bone biology and related diseases. It is the essential resource for anyone involved …

Parathyroid carcinoma is an uncommon cause of PTH-dependent hypercalcemia. The
collective published experience with this rare neoplasm has provided a distinctive clinical …

The extracellular calcium-sensing receptor (CaSR) plays a major role in the maintenance of
a physiological serum ionized calcium (Ca2+) concentration by regulating the circulating …

Purpose. Because parathyroid carcinoma is rare, clear consensus is not available regarding
the optimal management of patients with this condition. Treatment strategies generally …

The discovery of a G protein–coupled, calcium-sensing receptor (CaR) a decade ago and of
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …

Background: Management of inoperable parathyroid carcinoma presents a challenge
because until recently, effective medical therapy was not available. Morbidity and mortality …

Dr Marcocci claims a consultancy and lists himself as a member of the international advisory
board for Amgen. Dr Bilezikian has served as a consultant to Merck, Lilly, Amgen, NpS …