The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

Many advances in our understanding of the molecules that regulate the development,
differentiation and function of T cells have been made over the past few years. One …

Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was …

The vertebrate thymus provides an inductive environment for T-cell development. Within the
mouse thymus, Notch signals are indispensable for imposing the T-cell fate on multipotential …

The mb1 gene encodes the Ig-α signaling subunit of the B cell antigen receptor and is
expressed exclusively in B cells beginning at the very early pro-B cell stage in the bone …

Notch signalling is a central regulator of differentiation in a variety of organisms and tissue
types. Its activity is controlled by the multi-subunit γ-secretase (γSE) complex. Although …

Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation
process in which they gradually acquire T-cell characteristics while shedding their legacy of …

T cell development comprises a stepwise process of commitment from a multipotent
precursor. To define molecular mechanisms controlling this progression, we probed five …

The identities of the regulators that mediate commitment of hematopoietic precursors to the T
lymphocyte lineage have been unknown. The last stage of T lineage commitment in vivo …

All hematopoietic cells, including T lymphocytes, originate from stem cells that reside in the
bone marrow. Most hematopoietic lineages also mature in the bone marrow, but in this …