Advancements in the Preparation of 4H‐Chromenes: An Overview

Z Wen, KC Yang, JF Deng… - Advanced Synthesis & …, 2023 - Wiley Online Library
Functionalized 4H‐chromenes represent one class of the most important structural scaffolds
in both synthetic and medicinal chemistry. They often appear in an arrange of biological …

Brønsted acid catalyzed domino synthesis of functionalized 4H‐chromens and their ADMET, molecular docking and antibacterial studies

R Kshatriya, D Kambale, S Mali, VP Jejurkar… - …, 2019 - Wiley Online Library
Highly efficient catalytic one‐pot construction of 3‐acetyl‐4H‐chromene derivatives via a
tandem conjugate addition and cyclocondensation using p‐TSA catalyst was achieved …

[PDF][PDF] Multicomponent synthesis strategies, catalytic activities, and potential therapeutic potential of pyranocoumarins: a comprehensive review

M Jayalakshmi, F Joy, A Nizam, SBN Krishna - Chem. Biodiversity, 2023 - researchgate.net
Fused coumarins, because of their remarkable biological and therapeutic properties,
particularly pyranocoumarins, have caught the interest of synthetic organic chemists, leading …

Pd-Catalyzed Asymmetric Synthesis of Chiral 2-Trifluoromethyl-4-(indol-3-yl)-4H-chromene Derivatives

B Wang, L Sun, P Zhang, S Zhang, J Zhao… - The Journal of …, 2025 - ACS Publications
This paper presents a new strategy for the construction of the chiral 4 H-chromene skeleton.
A series of chiral 2-trifluoromethyl-4-(indol-3-yl)-4 H-chromenes were synthesized in …

Biotransformation of newly synthesized coumarin derivatives by Candida albicans as potential antibacterial, antioxidant and cytotoxic agents

S Haque, V Singh, D Katiyar, MTA Khan, V Tripathi… - Process …, 2019 - Elsevier
In this study, one bioactive coumarin analog was obtained as a result of biotransformation of
three inactive coumarin derivatives by free cells of Candida albicans. The bioactive analog …

Metal and Oxidant-Free Brønsted Acid-Mediated Cascade Reaction to Substituted Benzofurans

G Mari, C Ciccolini, L De Crescentini… - The Journal of …, 2019 - ACS Publications
Substituted hydroxy-benzofurans are easily accessible by treatment of resorcinols and 1, 2-
diaza-1, 3-dienes (DDs) under acidic conditions. The reaction happens through an …

Six-membered ring systems: with O and/or S atoms

CMM Santos, AMS Silva - Progress in Heterocyclic Chemistry, 2020 - Elsevier
The most interesting chemistry published in 2018 on the synthesis of O-and S-6-membered
heterocycles is reviewed. This personal overview is focused on the developments made on …

[PDF][PDF] Docking Studies, Synthesis and Evaluation of Anticancer Activity of 4H-Chromene Derivatives

P Kumar, P Rawat - INDIAN JOURNAL OF PHARMACEUTICAL …, 2021 - researchgate.net
Aim: The present study involves to design, synthesis and evaluate the anticancer activity of
4H-chromene derivatives (PKB 1-10) on human breast cancer MCF-7 cell line. Materials and …

Addition Reactions: Polar Addition

P Kočovský - Organic Reaction Mechanisms· 2016: An annual …, 2020 - Wiley Online Library
Summary This Chapter Contains Sections titled: Reviews Electrophilic Additions
Halogenation and Related Reactions (i) Bromine (ii) Chlorine (ii) Iodine (iv) Fluorine …

[PDF][PDF] SYNTHESIS OF MONO AND POLY-HETEROCYCLES STARTING FROM 1, 2-DIAZA-1, 3-DIENES (OR PRECURSORS) AS BUILDING BLOCKS

F Mantellini, G Favi, C Ciccolini - ora.uniurb.it
Nitrogen heterocycles are among the most significant components of natural and
pharmaceutical products. Indeed an analysis of database of US FDA approved drugs …