Complex brain disorders are highly heritable and arise from a complex polygenic risk
architecture. Many disease-associated loci are found in non-coding regions that house …

Over the course of the last decade, the biopharmaceutical industry has slowly adopted
human inducible pluripotent stem cell (hiPSC) technology to enable the development of …

Most neuropsychiatric disease risk variants are in noncoding sequences and lack functional
interpretation. Because regulatory sequences often reside in open chromatin, we reasoned …

Activity in the healthy brain relies on a concerted interplay of excitation (E) and inhibition (I)
via balanced synaptic communication between glutamatergic and GABAergic neurons. A …

Traditionally, in vitro generation of donor cells for brain repair has been dominated by the
application of extrinsic growth factors and morphogens. Recent advances in cell …

The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic,
demonstrates significant interindividual variability. In addition to showing more disease in …

Dopaminergic neurons are critical to movement, mood, addiction, and stress. Current
techniques for generating dopaminergic neurons from human induced pluripotent stem cells …

Schizophrenia (SZ) is a common and debilitating psychiatric disorder with limited effective
treatment options. Although highly heritable, risk for this polygenic disorder depends on the …

摘要: 转录因子Ascl1 可将体细胞重编程为诱导神经元, 包括将成纤维细胞, 星形胶质细胞, Müller
胶质细胞等体细胞重编程为不同的神经元亚型(多巴胺能神经元, 氨基酸类神经元等) …

Mutations affecting mTOR or RAS signaling underlie defined syndromes (the so-called
mTORopathies and RASopathies) with high risk for Autism Spectrum Disorder (ASD). These …