China's population has rapidly aged over the recent decades of social and economic
development as neurodegenerative disorders have proliferated, especially Alzheimer's …

Alzheimer's disease (AD) is the disease of lost memories. Synaptic loss is a major reason for
memory defects in AD. Signaling pathways involved in memory loss in AD are under intense …

Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the
proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However …

随着我国社会经济的发展和人口老龄化进程的加速, 与成功老龄化对应的老年性疾病对国民的
影响日益突出, 其中阿尔茨海默病(Aizheimer's disease, AD) 及相关认知障碍尤为突出和显著 …

Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most frequent
cause of progressive dementia in senior adults. It is characterized by memory loss and …

The transient receptor potential (TRP) ion channels are named after the discovery of the
photo-transducted channels in Drosophila. TRPs, activated by various extracellular and …

Mushroom dendritic spine structures are essential for memory storage and the loss of
mushroom spines may explain memory defects in aging and Alzheimer9s disease (AD). The …

Background The degeneration of the cholinergic circuit from the basal forebrain to the
hippocampus contributes to memory loss in patients suffering from Alzheimer's disease …

Sustained imbalance in intracellular calcium (Ca2+) entry and clearance alters cellular
integrity, ultimately leading to cellular homeostasis disequilibrium and cell death …

In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly
integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of …