Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

The therapeutic approach of targeted protein degradation (TPD) is gaining momentum due
to its potentially superior effects compared with protein inhibition. Recent advancements in …

Cell-penetrating peptides (CPPs) translocate into the cell as various biologically active
conjugates and possess numerous biomedical applications. Several machine learning …

Designing a therapeutic modality that will reach a certain organ, tissue, or cell type is crucial
for both the therapeutic efficiency and to limit off-target adverse effects. Nanoparticles …

Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the
remarkable ability to cross cell membranes and deliver various types of cargoes, including …

The development of intracellular ice in the bodies of cold-blooded living organisms may
cause them to die. These species yield antifreeze proteins (AFPs) to live in subzero …

Peptides comprise a versatile class of biomolecules that present a unique chemical space
with diverse physicochemical and structural properties. Some classes of peptides are able to …

Biophysical studies have a very high impact on the understanding of internalization,
molecular mechanisms, interactions, and localization of CPPs and CPP/cargo conjugates in …

Abstract Background Cell-penetrating peptides (CPPs) have received considerable attention
as a means of transporting pharmacologically active molecules into living cells without …

Cyclic peptides are gaining attention for their strong binding affinity, low toxicity, and ability
to target “undruggable” proteins; however, their therapeutic potential against intracellular …