Understanding the mysterious M2 macrophage through activation markers and effector mechanisms

T Rőszer - Mediators of inflammation, 2015 - Wiley Online Library
The alternatively activated or M2 macrophages are immune cells with high phenotypic
heterogeneity and are governing functions at the interface of immunity, tissue homeostasis …

CNS inflammation and neurodegeneration

T Chitnis, HL Weiner - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
There is an increasing recognition that inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …

Nitric oxide and the immune response

C Bogdan - Nature immunology, 2001 - nature.com
During the past two decades, nitric oxide (NO) has been recognized as one of the most
versatile players in the immune system. It is involved in the pathogenesis and control of …

Decline in nitrosative stress drives antibiotic persister regrowth during infection

S Ronneau, C Michaux, S Helaine - Cell Host & Microbe, 2023 - cell.com
Internalization of pathogenic bacteria by macrophages results in formation of antibiotic-
tolerant persisters. These cells are maintained in a non-growing state for extended periods …

Ribosomal protein S6: a potential therapeutic target against cancer?

YW Yi, KS You, JS Park, SG Lee, YS Seong - International journal of …, 2021 - mdpi.com
Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice

JM Crain, M Nikodemova… - Journal of neuroscience …, 2013 - Wiley Online Library
Although microglial activation is associated with all CNS disorders, many of which are
sexually dimorphic or age‐dependent, little is known about whether microglial basal gene …

Regulation of enzymes of the urea cycle and arginine metabolism

SM Morris Jr - Annual review of nutrition, 2002 - annualreviews.org
▪ Abstract The urea cycle is comprised of five enzymes but also requires other enzymes and
mitochondrial amino acid transporters to function fully. The complete urea cycle is expressed …

The molecular biology of chronic wounds and delayed healing in diabetes

R Blakytny, E Jude - Diabetic Medicine, 2006 - Wiley Online Library
Wound healing is a complicated and integrated process. Although there is some tolerance in
terms of redundancy and interrelated control mechanisms, pushing beyond such limits may …

Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine …

M Hesse, M Modolell, AC La Flamme… - The Journal of …, 2001 - journals.aai.org
Type 2 cytokines regulate fibrotic liver pathology in mice infected with Schistosoma mansoni.
Switching the immune response to a type 1-dominant reaction has proven highly effective at …

Role of nitric oxide in wound repair

MB Witte, A Barbul - The American Journal of Surgery, 2002 - Elsevier
After injury, wound healing is essential for recovery of the integrity of the body. It is a
complex, sequential cascade of events. Nitric oxide (NO) is a small radical, formed from the …