In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent
progenitors in a conserved order and are integrated into an intricate laminated architecture …

Fields such as genomics and systems biology are built on the synergism between
computational and experimental techniques. This type of synergism is especially important …

Gene co-expression networks capture biologically important patterns in gene expression
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …

Approximately 98% of mammalian DNA is noncoding, yet we understand relatively little
about the function of this enigmatic portion of the genome. The cis-regulatory elements that …

The identification of the genes underlying monogenic diseases has been of interest to
clinicians and scientists for many years. Using inherited retinal dystrophies as an example of …

Quantifying the differential expression of genes in various human organs, tissues, and cell
types is vital to understand human physiology and disease. Recently, several large‐scale …

Motivation: A major challenge in regulatory genomics is the identification of associations
between functional categories of genes (eg tissues, metabolic pathways) and their …

The photoreceptor cells of the retina are subject to a greater number of genetic diseases
than any other cell type in the human body. The majority of more than 120 cloned human …

Animal eyes can vary in complexity ranging from a single photoreceptor cell shaded by a
pigment cell to elaborate arrays of these basic units, which allow image formation in …

Retinal bipolar neurons serve as relay interneurons that connect rod and cone
photoreceptor cells to amacrine and ganglion cells. They exhibit diverse morphologies …