The role of oxidative stress and antioxidants in liver diseases
A complex antioxidant system has been developed in mammals to relieve oxidative stress.
However, excessive reactive species derived from oxygen and nitrogen may still lead to …
However, excessive reactive species derived from oxygen and nitrogen may still lead to …
Central role of glutamate metabolism in the maintenance of nitrogen homeostasis in normal and hyperammonemic brain
AJL Cooper, TM Jeitner - Biomolecules, 2016 - mdpi.com
Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in
excess of those of other amino acids. In glutamate-containing vesicles in the brain, the …
excess of those of other amino acids. In glutamate-containing vesicles in the brain, the …
Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy
EAR Abdelghffar, HAS El-Nashar, S Fayez… - Scientific Reports, 2022 - nature.com
Hepatic encephalopathy (HE) is a deterioration of brain function in patients suffering from
chronic liver disease, cirrhosis as a result of elevated blood ammonia and the production of …
chronic liver disease, cirrhosis as a result of elevated blood ammonia and the production of …
[HTML][HTML] The neurogliovascular unit in hepatic encephalopathy
Hepatic encephalopathy (HE) is a neurological complication of hepatic dysfunction and
portosystemic shunting. It is highly prevalent in patients with cirrhosis and is associated with …
portosystemic shunting. It is highly prevalent in patients with cirrhosis and is associated with …
A critical review on hepatoprotective effects of bioactive food components
Background: Bioactive food components are nonessential biomolecules, which help to give
beneficial effects to human being against several diseases. Natural bioactive food …
beneficial effects to human being against several diseases. Natural bioactive food …
Mitochondrial SIRT3 and neurodegenerative brain disorders
Sirtuins are highly conserved NAD+ dependent class III histone deacetylases and catalyze
deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require …
deacetylation and ADP ribosylation of a number of non-histone proteins. Since, they require …
Hippocampus mitochondrial MnSOD activation by a SIRT3 activator, honokiol, correlates with its deacetylation and upregulation of FoxO3a and PGC1α in a rat model …
We have recently reported that honokiol (HKL), by activating mitochondrial SIRT3,
normalizes reactive oxygen species level and mitochondrial integrity in hippocampus of the …
normalizes reactive oxygen species level and mitochondrial integrity in hippocampus of the …
Gastroprotective effect of hydromethanolic extract of Ayapana triplinervis leaves on indomethacin‐induced gastric ulcer in male Wistar rats
R Maity, P Mondal, MK Giri, C Ghosh… - Journal of food …, 2021 - Wiley Online Library
This study investigated the gastroprotective effect of Ayapana triplinervis leaves against
indomethacin‐induced gastric ulcer in male albino rat. Gastric ulceration was developed by …
indomethacin‐induced gastric ulcer in male albino rat. Gastric ulceration was developed by …
Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats
Malnutrition and low dietary protein intake could be risk factors for developing peripheral
and central hyperammonemia, especially in pediatrics. Both curcumin and resveratrol …
and central hyperammonemia, especially in pediatrics. Both curcumin and resveratrol …
Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase
Hyperammonemia is the common biochemical hallmark of urea cycle disorders, activating
neurotoxic pathways. If untreated, affected individuals have a high risk of irreversible brain …
neurotoxic pathways. If untreated, affected individuals have a high risk of irreversible brain …