Asthma manifests as airway hyperresponsiveness and inflammation, including coughing,
wheezing, and shortness of breath. Immune cells and airway structural cells orchestrate …

Phosphoinositide 3-kinases (PI3Ks) are a family of ubiquitously distributed lipid kinases that
control a wide variety of intracellular signaling pathways. Over the years, PI3K has emerged …

Cigarette smoke contributes to or exacerbates airway diseases such as asthma and COPD,
where airway hyperresponsiveness and airway smooth muscle (ASM) proliferation are key …

Background The cell-surface protein CD38 mediates airway smooth muscle (ASM)
contractility by generating cyclic ADP-ribose, a calcium-mobilizing molecule. In human ASM …

Background and Purpose Asthma manifests as a heterogeneous syndrome characterized by
airway obstruction, inflammation and hyperresponsiveness (AHR). Although the molecular …

Asthma is an inflammatory disease in which altered calcium regulation, contractility, and
airway smooth muscle (ASM) proliferation contribute to airway hyper-responsiveness and …

The various roles of microRNAs (miRNAs) in the epigenetic regulation of human disease are
gaining importance as areas of research, and a better understanding of these roles may …

Notch1 has been implicated in asthma pathogenesis. However, the function of Notch1 in
regulating airway smooth muscle (ASM) cell proliferation and migration during airway …

Both phosphatase and tensin homologue deleted on chromosome ten (PTEN) and cluster of
differentiation 38 (CD38) have been suggested to be key regulators of the pathogenesis of …

Background and Purpose PI3K‐dependent activation of Rho kinase (ROCK) is necessary for
agonist‐induced human airway smooth muscle cell (HASMC) contraction, and inhibition of …