The oral minimal model method
The simultaneous assessment of insulin action, secretion, and hepatic extraction is key to
understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We …
understanding postprandial glucose metabolism in nondiabetic and diabetic humans. We …
Mathematical modeling of the glucose–insulin system: A review
P Palumbo, S Ditlevsen, A Bertuzzi… - Mathematical …, 2013 - Elsevier
Mathematical modeling of the glucose–insulin feedback system is necessary to the
understanding of the homeostatic control, to analyze experimental data, to identify and …
understanding of the homeostatic control, to analyze experimental data, to identify and …
[HTML][HTML] Role of reduced β-cell mass versus impaired β-cell function in the pathogenesis of type 2 diabetes
JJ Meier, RC Bonadonna - Diabetes care, 2013 - ncbi.nlm.nih.gov
Although it has long been assumed that insulin resistance is the leading factor in the
pathogenesis of type 2 diabetes (1), evidence for the importance of the pancreatic β-cells …
pathogenesis of type 2 diabetes (1), evidence for the importance of the pancreatic β-cells …
[HTML][HTML] In vivo photoacoustic monitoring of vasoconstriction induced by acute hyperglycemia
Postprandial hyperglycemia, blood glucose spikes, induces endothelial dysfunction,
increasing cardiovascular risks. Endothelial dysfunction leads to vasoconstriction, and …
increasing cardiovascular risks. Endothelial dysfunction leads to vasoconstriction, and …
The impact of mathematical modeling on the understanding of diabetes and related complications
I Ajmera, M Swat, C Laibe, N Le Novere… - CPT …, 2013 - Wiley Online Library
Diabetes is a chronic and complex multifactorial disease caused by persistent
hyperglycemia and for which underlying pathogenesis is still not completely understood …
hyperglycemia and for which underlying pathogenesis is still not completely understood …
Toward a fully automated artificial pancreas system using a bioinspired reinforcement learning design: In silico validation
Objective: The automation of insulin treatment is the most challenge aspect of glucose
management for type 1 diabetes owing to unexpected exogenous events (eg, meal intake) …
management for type 1 diabetes owing to unexpected exogenous events (eg, meal intake) …
A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
P Buchwald - Theoretical biology and medical modelling, 2011 - Springer
Background Because insulin is the main regulator of glucose homeostasis, quantitative
models describing the dynamics of glucose-induced insulin secretion are of obvious interest …
models describing the dynamics of glucose-induced insulin secretion are of obvious interest …
Enhancing automatic closed-loop glucose control in type 1 diabetes with an adaptive meal bolus calculator–in silico evaluation under intra-day variability
Abstract Background and Objective Current prototypes of closed-loop systems for glucose
control in type 1 diabetes mellitus, also referred to as artificial pancreas systems, require a …
control in type 1 diabetes mellitus, also referred to as artificial pancreas systems, require a …
Reinforcement learning models and algorithms for diabetes management
With the advancements in reinforcement learning (RL), new variants of this artificial
intelligence approach have been introduced in the literature. This has led to increased …
intelligence approach have been introduced in the literature. This has led to increased …
Conclusions via unique predictions obtained despite unidentifiability–new definitions and a general method
G Cedersund - The FEBS journal, 2012 - Wiley Online Library
It is often predicted that model‐based data analysis will revolutionize biology, just as it has
physics and engineering. A widely used tool within such analysis is hypothesis testing …
physics and engineering. A widely used tool within such analysis is hypothesis testing …