Molecular logic of neocortical projection neuron specification, development and diversity

LC Greig, MB Woodworth, MJ Galazo… - Nature Reviews …, 2013 - nature.com
The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …

The genetic architecture of the human cerebral cortex

KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …

Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology

C Tocco, M Bertacchi, M Studer - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
The assembly and maturation of the mammalian brain result from an intricate cascade of
highly coordinated developmental events, such as cell proliferation, migration, and …

Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications

K Harb, E Magrinelli, CS Nicolas, N Lukianets… - Elife, 2016 - elifesciences.org
During cortical development, the identity of major classes of long-distance projection
neurons is established by the expression of molecular determinants, which become …

Glycosphingolipid metabolic reprogramming drives neural differentiation

D Russo, F Della Ragione, R Rizzo, E Sugiyama… - The EMBO …, 2018 - embopress.org
Neural development is accomplished by differentiation events leading to metabolic
reprogramming. Glycosphingolipid metabolism is reprogrammed during neural development …

Ctip1 controls acquisition of sensory area identity and establishment of sensory input fields in the developing neocortex

LC Greig, MB Woodworth, C Greppi, JD Macklis - Neuron, 2016 - cell.com
While transcriptional controls over the size and relative position of cortical areas have been
identified, less is known about regulators that direct acquisition of area-specific …

Postmitotic control of sensory area specification during neocortical development

C Alfano, E Magrinelli, K Harb, RF Hevner… - Nature …, 2014 - nature.com
The mammalian neocortex is subdivided into cytoarchitectural areas with distinct
connectivity, gene expression and neural functions. Areal identity is initially specified by …

Regional and hemispheric asymmetries of cerebral hemodynamic and oxygen metabolism in newborns

PY Lin, N Roche-Labarbe, M Dehaes… - Cerebral …, 2013 - academic.oup.com
Understanding the evolution of regional and hemispheric asymmetries in the early stages of
life is essential to the advancement of developmental neuroscience. By using 2 noninvasive …

Lmo4 establishes rostral motor cortex projection neuron subtype diversity

GY Cederquist, E Azim, SJ Shnider… - Journal of …, 2013 - Soc Neuroscience
The mammalian neocortex is parcellated into anatomically and functionally distinct areas.
The establishment of area-specific neuronal diversity and circuit connectivity enables distinct …

Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity

EA Clark, M Rutlin, LS Capano, S Aviles, JR Saadon… - Elife, 2020 - elifesciences.org
Retinoic acid-related orphan receptor beta (RORβ) is a transcription factor (TF) and marker
of layer 4 (L4) neurons, which are distinctive both in transcriptional identity and the ability to …