Trapped ion mobility spectrometry: A short review

ME Ridgeway, M Lubeck, J Jordens, M Mann… - International journal of …, 2018 - Elsevier
Trapped ion mobility spectrometry (TIMS) hybridized with mass spectrometry (MS) is a
relatively recent advance in the field of ion mobility mass spectrometry (IMMS). The basic …

Trapped ion mobility spectrometry and parallel accumulation–serial fragmentation in proteomics

F Meier, MA Park, M Mann - Molecular & Cellular Proteomics, 2021 - ASBMB
Recent advances in efficiency and ease of implementation have rekindled interest in ion
mobility spectrometry, a technique that separates gas phase ions by their size and shape …

Fundamentals of trapped ion mobility spectrometry

K Michelmann, JA Silveira, ME Ridgeway… - Journal of the …, 2014 - ACS Publications
Trapped ion mobility spectrometry (TIMS) is a relatively new gas-phase separation method
that has been coupled to quadrupole orthogonal acceleration time-of-flight mass …

Correlating resolving power, resolution, and collision cross section: unifying cross-platform assessment of separation efficiency in ion mobility spectrometry

JN Dodds, JC May, JA McLean - Analytical chemistry, 2017 - ACS Publications
Here we examine the relationship among resolving power (R p), resolution (R pp), and
collision cross section (CCS) for compounds analyzed in previous ion mobility (IM) …

Deep learning the collisional cross sections of the peptide universe from a million experimental values

F Meier, ND Köhler, AD Brunner, JMH Wanka… - Nature …, 2021 - nature.com
The size and shape of peptide ions in the gas phase are an under-explored dimension for
mass spectrometry-based proteomics. To investigate the nature and utility of the peptide …

Cryogenic ion trap vibrational spectroscopy of hydrogen-bonded clusters relevant to atmospheric chemistry

N Heine, KR Asmis - International Reviews in Physical Chemistry, 2015 - Taylor & Francis
Recent advances in the gas phase vibrational spectroscopy of mass-selected ions are
described, highlighting experiments on hydrogen-bonded (HBed) clusters relevant to …

High resolution trapped ion mobility spectrometery of peptides

JA Silveira, ME Ridgeway, MA Park - Analytical chemistry, 2014 - ACS Publications
In the present work, we employ trapped ion mobility spectrometry (TIMS) for conformational
analysis of several model peptides. The TIMS distributions are extensively compared to …

Ion mobility analysis of molecular dynamics

T Wyttenbach, NA Pierson, DE Clemmer… - Annual review of …, 2014 - annualreviews.org
The combination of mass spectrometry and ion mobility spectrometry (IMS) employing a
temperature-variable drift cell or a drift tube divided into sections to make IMS-IMS …

Retention of native protein structures in the absence of solvent: a coupled ion mobility and spectroscopic study

J Seo, W Hoffmann, S Warnke… - Angewandte Chemie …, 2016 - Wiley Online Library
Can the structures of small to medium‐sized proteins be conserved after transfer from the
solution phase to the gas phase? A large number of studies have been devoted to this topic …

Identification of Conformational Variants for Bradykinin Biomarker Peptides from a Biofluid Using a Nanopore and Machine Learning

SJ Greive, L Bacri, B Cressiot, J Pelta - ACS nano, 2023 - ACS Publications
There is a current need to develop methods for the sensitive detection of peptide biomarkers
in complex mixtures of molecules, such as biofluids, to enable early disease detection …