Unexpected guests in the tumor microenvironment: microbiome in cancer

A Wong-Rolle, HK Wei, C Zhao, C Jin - Protein & cell, 2021 - academic.oup.com
Although intestinal microbiome have been established as an important biomarker and
regulator of cancer development and therapeutic response, less is known about the role of …

Emerging roles of ECM remodeling processes in cancer

V Mohan, A Das, I Sagi - Seminars in cancer biology, 2020 - Elsevier
Extracellular matrix (ECM) plays a central and dynamic role in the creation of tumor
microenvironment. Herein we discuss the emerging biophysical and biochemical aspects of …

[HTML][HTML] Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer

A Fu, B Yao, T Dong, Y Chen, J Yao, Y Liu, H Li, H Bai… - Cell, 2022 - cell.com
Tumor-resident intracellular microbiota is an emerging tumor component that has been
documented for a variety of cancer types with unclear biological functions. Here, we …

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

D Nejman, I Livyatan, G Fuks, N Gavert, Y Zwang… - Science, 2020 - science.org
Bacteria were first detected in human tumors more than 100 years ago, but the
characterization of the tumor microbiome has remained challenging because of its low …

Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer

A Tzeng, N Sangwan, M Jia, CC Liu, KS Keslar… - Genome Medicine, 2021 - Springer
Background Currently, over half of breast cancer cases are unrelated to known risk factors,
highlighting the importance of discovering other cancer-promoting factors. Since crosstalk …

Breast cancer and its relationship with the microbiota

MF Fernández, I Reina-Pérez, JM Astorga… - International journal of …, 2018 - mdpi.com
The microorganisms that live symbiotically in human beings are increasingly recognized as
important players in health and disease. The largest collection of these microorganisms is …

A procarcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates notch and β-catenin axes

S Parida, S Wu, S Siddharth, G Wang, N Muniraj… - Cancer discovery, 2021 - AACR
The existence of distinct breast microbiota has been recently established, but their biological
impact in breast cancer remains elusive. Focusing on the shift in microbial community …

Current concepts, opportunities, and challenges of gut microbiome-based personalized medicine in nonalcoholic fatty liver disease

SR Sharpton, B Schnabl, R Knight, R Loomba - Cell metabolism, 2021 - cell.com
Nonalcoholic fatty liver disease (NALFD) is now a leading cause of chronic liver disease
worldwide, in part, as a consequence of rapidly rising levels of obesity and metabolic …

[HTML][HTML] Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions

L Narunsky-Haziza, GD Sepich-Poore, I Livyatan… - Cell, 2022 - cell.com
Cancer-microbe associations have been explored for centuries, but cancer-associated fungi
have rarely been examined. Here, we comprehensively characterize the cancer mycobiome …

The role of the cervicovaginal microbiome on the genesis and as a biomarker of premalignant cervical intraepithelial neoplasia and invasive cervical cancer

G Curty, PS de Carvalho, MA Soares - International journal of molecular …, 2019 - mdpi.com
The microbiome is able to modulate immune responses, alter the physiology of the human
organism, and increase the risk of viral infections and development of diseases such as …