Amide bond construction has garnered significant interest in recent decades due to amides
being one of the most prevalent functional groups among bioactive molecules. Out of the …

The Beckmann rearrangement, named after the German chemist Ernst Otto Beckmann
(1853–1923), is an acid catalyzed rearrangement of an oxime to an amide. The Beckmann …

Catalytic activation of hydroxyl functionalities is of great interest for the production of
pharmaceuticals and commodity chemicals. Here, 2-alkoxycarbonyl-and 2-phenoxycarbonyl …

Discovered over a century ago, Beckmann rearrangement is still today fully compliant with
all the green chemistry principles and consistent with the key aspects of sustainable …

The first three primary members of the non‐benzenoid carbocyclic aromatic ion family,
namely cyclopropenium, cyclopentadienide, and cycloheptatrienium (tropylium) ions, have …

A novel protocol for the activation of the Beckmann rearrangement utilizing the readily
available and economical geminal dichloroimidazolidinediones (DCIDs) on a …

The Beckmann rearrangement has been predominantly studied for the synthesis of amide
and lactam. By strategically using the in situ generated Appel's salt or Mitsunobu's …

The formation of amide bonds is one of the most valuable transformations in organic
synthesis. Beckmann rearrangement is a well-known method for producing secondary …

The Beckmann rearrangement of oximes to amides typically requires strong acids or highly
reactive, hazardous electrophiles and/or elevated temperatures to proceed. A very attractive …

Herein, an aerobic reconstruction of amines to amides via C (sp3)–N bond and C (sp2)–C
(sp3) bond cleavage is described. This method features a metal-free reaction, insensitivity to …