The roles of K+ channels in cancer

LA Pardo, W Stühmer - Nature Reviews Cancer, 2014 - nature.com
Potassium channels are transmembrane proteins that selectively facilitate the flow of
potassium ions down an electrochemical gradient. These molecules have been studied in …

Retinoic acid signaling and neuronal differentiation

A Janesick, SC Wu, B Blumberg - Cellular and Molecular Life Sciences, 2015 - Springer
The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …

K+ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

M Choi, UI Scholl, P Yue, P Björklund, B Zhao… - Science, 2011 - science.org
Endocrine tumors such as aldosterone-producing adrenal adenomas (APAs), a cause of
severe hypertension, feature constitutive hormone production and unrestrained cell …

[HTML][HTML] The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer

MW Berchtold, A Villalobo - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
Calmodulin (CaM) is a ubiquitous Ca 2+ receptor protein mediating a large number of
signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of …

Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival

HL Roderick, SJ Cook - Nature Reviews Cancer, 2008 - nature.com
Increases in cytosolic free Ca2+ ([Ca2+] i) represent a ubiquitous signalling mechanism that
controls a variety of cellular processes, including proliferation, metabolism and gene …

Conformational entropy in molecular recognition by proteins

KK Frederick, MS Marlow, KG Valentine, AJ Wand - Nature, 2007 - nature.com
Molecular recognition by proteins is fundamental to almost every biological process,
particularly the protein associations underlying cellular signal transduction. Understanding …

Calcium signaling and cell proliferation

MCX Pinto, AH Kihara, VAM Goulart, FMP Tonelli… - Cellular signalling, 2015 - Elsevier
Cell proliferation is orchestrated through diverse proteins related to calcium (Ca 2+)
signaling inside the cell. Cellular Ca 2+ influx that occurs first by various mechanisms at the …

Physiological and unappreciated roles of CaMKII in the heart

J Beckendorf, MMG van den Hoogenhof… - Basic research in …, 2018 - Springer
In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation–
contraction and also excitation–transcription coupling. Its activity can be regulated in …

Mitogenic signaling pathways induced by G protein‐coupled receptors

E Rozengurt - Journal of cellular physiology, 2007 - Wiley Online Library
G protein‐coupled receptor (GPCR) agonists, including neurotransmitters, hormones,
chemokines, and bioactive lipids, act as potent cellular growth factors and have been …

[HTML][HTML] Plasma membrane calcium channels in cancer: Alterations and consequences for cell proliferation and migration

N Déliot, B Constantin - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
The study of calcium channels in molecular mechanisms of cancer transformation is still a
novel area of research. Several studies, mostly conducted on cancer cell lines, however …