Several families of protein kinases orchestrate the complex events that drive the cell cycle,
and their activity is frequently deregulated in hyperproliferative cancer cells. Although …

The process by which normal cells become progressively transformed to malignancy is now
known to require the sequential acquisition of mutations which arise as a consequence of …

Over the past decade, studies focusing on the mechanisms controlling cellular proliferation
have converged with equally intensive efforts directed at the analysis of oncogenic pathways …

Background: The recently identified RASSF1 locus is located within a 120-kilobase region of
chromosome 3p21. 3 that frequently undergoes allele loss in lung and breast cancers. We …

A key event in the regulation of eukaryotic gene expression is the posttranslational
modification of nucleosomal histones, which converts regions of chromosomes into …

The retinoblastoma protein, pRB, and the closely related proteins p107 and p130 are
important regulators of the mammalian cell cycle. Biochemical and genetic studies have …

Inactivation of the retinoblastoma (RB1) tumor suppressor is one of the most frequent and
early recognized molecular hallmarks of cancer. RB1, although mainly studied for its role in …

In recent years several new mouse models for lung cancer have been described. These
include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer …

Cancer cells exhibit a set of unique properties that distinguish them from their normal
counterparts. Among these features are increased growth rates, loss of differentiation …

p107 and p130 were originally identified as targets of the transforming domains of viral
oncoproteins encoded by small DNA tumor viruses. Together with pRB, the protein product …