Cancer development is closely associated with immunosuppressive tumor
microenvironment (TME) that attenuates antitumor immune responses and promotes tumor …

The immunosuppressive effect of adenosine in the microenvironment of a tumor is well
established. Presently, researchers are developing approaches in immune therapy that …

The ATP-adenosine pathway functions as a key modulator of innate and adaptive immunity
within the tumor microenvironment, and cancer immune evasion largely involves the …

As a new pillar of cancer therapy, tumor immunotherapy has brought irreplaceable durable
responses in tumors. Considering its low response rate, additional immune regulatory …

Dendritic cells (DCs) can present tumoral antigens to T-cells and stimulate T-cell-mediated
anti-tumoral immune responses. In addition to uptaking, processing, and presenting tumoral …

Lenvatinib is a multikinase inhibitor which mainly hinders liver cancer proliferation by
inhibiting angiogenesis. In 2018, Lenvatinib was approved for the first-line treatment of …

CD73, a cell surface‐bound nucleotidase, facilitates extracellular adenosine formation by
hydrolyzing 5′‐AMP to adenosine. Several studies have shown that CD73 plays an …

Acute myeloid leukemia (AML) comprises a multifarious and heterogeneous array of
illnesses characterized by the anomalous proliferation of myeloid cells in the bone marrow …

Purines and pyrimidines are signaling molecules in the tumor microenvironment that affect
cancer immunity. The purinergic signaling pathways have been shown to play an important …

Abstract Adenosine 5′-triphosphate (ATP) is a vital element in energy information. It plays a
critical role in transmitting signals inside the body, which is necessary for controlling the life …