[PDF][PDF] Sex-stratified genome-wide association and transcriptome-wide Mendelian randomization studies reveal drug targets of heart failure
The prevalence of heart failure (HF) subtypes, which are classified by left ventricular ejection
fraction (LVEF), demonstrate significant sex differences. Here, we perform sex-stratified …
fraction (LVEF), demonstrate significant sex differences. Here, we perform sex-stratified …
Integrating urinary and plasma omics to identify markers and therapeutic targets for cardiac disease
SC de Ruiter, M van Vugt, C Finan, R Providencia… - medRxiv, 2024 - medrxiv.org
Introduction: Urinary metabolites, representing kidney regulated filtration of metabolism end
products, contain cardiac disease biomarkers such as NT-proBNP. We set out to integrate …
products, contain cardiac disease biomarkers such as NT-proBNP. We set out to integrate …
Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation
Background Altered metabolism plays a role in the pathophysiology of cardiac diseases,
such as atrial fibrillation (AF) and heart failure (HF). We aimed to identify novel plasma …
such as atrial fibrillation (AF) and heart failure (HF). We aimed to identify novel plasma …
Large-scale Mendelian randomization identifies novel pathways as therapeutic targets for heart failure with reduced ejection fraction and with preserved ejection …
We used expression quantitative trait loci (eQTLs) and protein quantitative trait loci (pQTLs)
to conduct genome-wide Mendelian randomization (MR) using 27,799 cases of heart failure …
to conduct genome-wide Mendelian randomization (MR) using 27,799 cases of heart failure …