Adipose tissue has traditionally been defined as connective tissue that stores excess
calories in the form of triacylglycerol. However, the physiologic functions attributed to …

Background Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from
simple hepatic steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which may …

Since the discovery of adipose tissue as a higly active endocrine tissue, adipokines,
peptides produced by adipose tissue and exerting autocrine, paracrine and endocrine …

Non-alcoholic fatty liver disease (NAFLD) is caused by an accumulation of fat in the liver; the
condition can progress over time to increase the risk of developing cirrhosis, end-stage liver …

The incidence of hepatocellular carcinoma (HCC) is increasing in industrialized societies;
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …

Nonalcoholic steatohepatitis (NASH) is the main cause of chronic liver disease in the
Western world and a major health problem, owing to its close association with obesity …

Background & Aims microRNAs (miRNAs) are deregulated in non-alcoholic fatty liver
disease (NAFLD) and have been proposed as useful markers for the diagnosis and …

MicroRNAs are small non-coding RNAs that range in length from 18 to 24 nucleotides. As
one of the most extensively studied microRNAs, microRNA-21 (miR-21) is highly expressed …

Since its discovery twenty-five years ago, the fat-derived hormone leptin has provided a
revolutionary framework for studying the physiological role of adipose tissue as an …

Chronic kidney disease (CKD) is a risk factor for end-stage renal disease (ESRD) and
cardiovascular disease (CVD). ESRD or CVD develop in a substantial proportion of patients …