Cryptosporidium parasites replicate within intestinal epithelial cells and are an important
cause of diarrhoeal disease in young children and in patients with primary and acquired …

Cell death is an essential immunological apparatus of host defense, but dysregulation of
mutually inclusive cell deaths poses severe threats during microbial and parasitic infections …

Cryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor
settings. The majority of infections are caused by the human-specific pathogen C. hominis …

The nucleotide-binding oligomerization and leucine-rich repeat receptor (NLR) protein
family consists of important immune sensors that form inflammasomes, a cytosolic multi …

Inflammasomes are multi‐protein complexes that assemble within the cytoplasm of
mammalian cells in response to pathogen‐associated molecular patterns (PAMPs) or …

The parasite Cryptosporidium invades and replicates in intestinal epithelial cells and is a
leading cause of diarrheal disease and early childhood mortality. The molecular …

The physical barrier of the intestine and associated mucosal immunity maintains a delicate
homeostatic balance between the host and the external environment by regulating immune …

Abstract Purpose of Review Cryptosporidium spp.(C. hominis and C. parvum) are a major
cause of diarrhea-associated morbidity and mortality in young children globally. While C …

The intestinal parasite, Cryptosporidium, is a major contributor to global child mortality and
causes opportunistic infection in immune deficient individuals. Innate resistance to …

Cryptosporidium causes debilitating diarrheal disease in patients with primary and acquired
defects in T cell function. However, it has been a challenge to understand how this infection …