In recent decades, the development of new drugs has become increasingly expensive and
inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly …

Network approaches hold promise for unraveling the impact of comorbidities in the complex
presentation and genetics of HF. Methods that consider comorbidity presence and timing …

Gene regulatory networks (GRNs) and gene co-expression networks (GCNs) allow genome-
wide exploration of molecular regulation patterns in health and disease. The standard …

Arthritis, a diverse group of inflammatory joint disorders, poses great challenges in early
diagnosis and targeted treatment. Timely intervention is imperative, yet conventional …

The categorization of human diseases is mainly based on the affected organ system and
phenotypic characteristics. This is limiting the view to the pathological manifestations, while …

A novel virus emerged from Wuhan, China, at the end of 2019 and quickly evolved into a
pandemic, significantly impacting various industries, especially healthcare. One critical …

The dissertation seeks to improve drug research efficiency through drug repurposing, the
exploration of new applications for existing drugs. The dissertation presents CoVex …

In cancer, most somatic mutation are so-called passenger mutations with no functional
impact on disease development. Only a subset of the mutations act as drivers and are …

Heart failure (HF) represents an immense health burden with currently no curative
therapeutic strategies. Study of HF patient heterogeneity has led to the recognition of HF …

Gene co-expression networks (GCNs) are networks with genes as nodes and edges that
indicate correlation between two genes' expression profiles across several samples. Since …