Venom biotechnology: casting light on nature's deadliest weapons using synthetic biology

T Lüddecke, A Paas, RJ Harris, L Talmann… - … in bioengineering and …, 2023 - frontiersin.org
Venoms are complex chemical arsenals that have evolved independently many times in the
animal kingdom. Venoms have attracted the interest of researchers because they are an …

Ocular sequelae of snakebite envenoming: A review of the indirect effects of snakebite envenoming on the eye

MB Jalink, J van Thiel, RM Wouters, FJ Vonk… - Toxin …, 2024 - Taylor & Francis
Snakebite envenoming is a major public health issue in developing, often agricultural-
based, tropical countries, which causes substantial mortality and morbidity. Most studies …

Intraspecific venom variation in the medically important puff adder (Bitis arietans): Comparative venom gland transcriptomics, in vitro venom activity and …

CA Dawson, KE Bartlett, MC Wilkinson… - PLOS Neglected …, 2024 - journals.plos.org
Background Variation in snake venoms is well documented, both between and within
species, with intraspecific venom variation often correlated with geographically distinct …

Rodent lethality models are problematic for evaluating antivenoms for human envenoming

A Silva, WC Hodgson, T Tasoulis… - Frontiers in …, 2022 - frontiersin.org
Snakebite is a major public health problem in the tropics, being closely associated with
agricultural economy, poverty and underdevelopment. The neglected nature of the condition …

Compendium of medically important snakes, venom activity and clinical presentations in Ghana

JP Deikumah, RP Biney… - PLOS Neglected …, 2023 - journals.plos.org
Background Snake bite envenoming (SBE) is one neglected tropical disease that has not
received the needed attention. The sequelae of burdensome disability and mortality impact …

Diverse and Dynamic Alpha-Neurotoxicity Within Venoms from the Palearctic Viperid Snake Clade of Daboia, Macrovipera, Montivipera, and Vipera

A Chowdhury, CN Zdenek, BG Fry - Neurotoxicity Research, 2022 - Springer
The targeting of specific prey by snake venom toxins is a fascinating aspect of molecular and
ecological evolution. Neurotoxic targeting by elapid snakes dominates the literature in this …

Comparative Analysis of Alpha-1 Orthosteric-Site Binding by a Clade of Central American Pit Vipers (Genera Atropoides, Cerrophidion, Metlapilcoatlus, and …

L Jones, C Waite, E Neri-Castro, BG Fry - Toxins, 2023 - mdpi.com
The distribution and relative potency of post-synaptic neurotoxic activity within Crotalinae
venoms has been the subject of less investigation in comparison with Elapidae snake …

Extreme Procoagulant Potency in Human Plasma of Venoms from the African Viperid Genera Atheris, Cerastes, and Proatheris and the Relative Efficacy of …

A Chowdhury, MR Lewin, R Carter, R Soria, M Aldridge… - Toxins, 2022 - mdpi.com
The African viperid snake genera Atheris, Cerastes, and Proatheris are closely related,
similar in size, but occupy extremely divergent ecological niches (arboreal in tropical …

Getting stoned: Characterisation of the coagulotoxic and neurotoxic effects of reef stonefish (Synanceia verrucosa) venom

RJ Harris, NJ Youngman, W Chan, F Bosmans… - Toxicology letters, 2021 - Elsevier
The reef stonefish (Synanceia verrucosa) is a venomous fish which causes excruciatingly
painful envenomations. While some research on the pathophysiology and functions of the …

Differential coagulotoxic and neurotoxic venom activity from species of the arboreal viperid snake genus Bothriechis (palm-pitvipers)

NJ Youngman, YH Peng, RJ Harris, L Jones… - … and Physiology Part C …, 2022 - Elsevier
The viperid snake genus Bothriechis consists of eleven species distributed among Central
and South America, living across low and high-altitude habitats. Despite Bothriechis …