Cancer stem‐like cells (CSCs) are thought to be the main cause of tumor occurrence,
progression and therapeutic resistance. Strong research efforts in the last decade have led …

The accurate function of the central nervous system (CNS) depends of the consonance of
multiple genetic programs and external signals during the ontogenesis. A variety of …

In recent years, several studies described the close relationship between the composition of
gut microbiota and brain functions, highlighting the importance of gut-derived metabolites in …

The cell nucleus is an interesting target in many diseases with particular interest in cancer.
Previously, nuclear targeted small and large chitosan nanoparticles (S-NPs≈ 25 nm, and L …

Key points The nucleus accumbens (nAc) is involved in addiction‐related behaviour caused
by several drugs of abuse, including alcohol. Glycine receptors (GlyRs) are potentiated by …

Glycine receptors (GlyRs) are anion-permeable pentameric ligand-gated ion channels
(pLGICs). The GlyR activation is critical for the control of key neurophysiological functions …

The family of Cys-loop receptors (CLRs) shares a high degree of homology and sequence
identity. The overall structural elements are highly conserved with a large extracellular …

Recent advances in sequencing technologies led to the identification of a plethora of
different genes and several hundreds of amino acid recoding edited positions. Changes in …

C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease
progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific …

Glycine receptors (GlyRs) are ligand-gated pentameric chloride channels in the central
nervous system. GlyR-α3 is a possible target for chronic pain treatment and temporal lobe …