Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets

F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Eosinophilic esophagitis: Immune mechanisms and therapeutic targets

D Khokhar, S Marella, G Idelman… - Clinical & …, 2022 - Wiley Online Library
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy

Y Chen, T Jiang, H Zhang, X Gou, C Han, J Wang… - Nature cell …, 2020 - nature.com
Breast cancer brain metastasis (BCBM) is a devastating disease. Radiation therapy remains
the mainstay for treatment of this disease. Unfortunately, its efficacy is limited by the dose …

Epithelial origin of eosinophilic esophagitis

M Rochman, NP Azouz, ME Rothenberg - Journal of Allergy and Clinical …, 2018 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic, allergen-driven inflammatory disease of the
esophagus characterized predominantly by eosinophilic inflammation, leading to …

Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid‐treated eosinophilic esophagitis

D Simon, B Page, M Vogel, C Bussmann, C Blanchard… - Allergy, 2018 - Wiley Online Library
Abstract Background Eosinophilic esophagitis (EoE) is a chronic, immune/antigen‐mediated
disease characterized by symptoms related to esophageal dysfunction and an eosinophil …

Profound loss of esophageal tissue differentiation in patients with eosinophilic esophagitis

M Rochman, J Travers, CE Miracle, MC Bedard… - Journal of Allergy and …, 2017 - Elsevier
Background A key question in the allergy field is to understand how tissue-specific disease
is manifested. Eosinophilic esophagitis (EoE) is an emerging tissue-specific allergic disease …

[HTML][HTML] Esophageal 3D culture systems as modeling tools in esophageal epithelial pathobiology and personalized medicine

KA Whelan, AB Muir, H Nakagawa - Cellular and molecular …, 2018 - Elsevier
The stratified squamous epithelium of the esophagus shows a proliferative basal layer of
keratinocytes that undergo terminal differentiation in overlying suprabasal layers …

Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes

LC Kottyan, MP Trimarchi, X Lu, JM Caldwell… - Journal of Allergy and …, 2021 - Elsevier
Background Eosinophilic esophagitis (EoE) is an emerging, chronic, rare allergic disease
associated with marked eosinophil accumulation in the esophagus. Previous genome-wide …

A synthesis and subgroup analysis of the eosinophilic esophagitis tissue transcriptome

J Jacobse, R Brown, F Revetta, M Vaezi… - Journal of Allergy and …, 2024 - Elsevier
Background Eosinophilic esophagitis (EoE) is a chronic immune mediated inflammatory
disorder of the esophagus. It is still unknown why children and adults present differently, and …

IL-13–induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis

S Marella, A Sharma, V Ganesan… - Journal of Allergy and …, 2023 - Elsevier
Background Basal zone hyperplasia (BZH) and dilated intercellular spaces (DISs) are
thought to contribute to the clinical manifestations of eosinophilic esophagitis (EoE); …