Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

The human gut microbiota: a key mediator of osteoporosis and osteogenesis

KD Seely, CA Kotelko, H Douglas, B Bealer… - International journal of …, 2021 - mdpi.com
An expanding body of research asserts that the gut microbiota has a role in bone
metabolism and the pathogenesis of osteoporosis. This review considers the human gut …

Gut microbiota status in COVID-19: an unrecognized player?

S Donati Zeppa, D Agostini, G Piccoli… - Frontiers in cellular …, 2020 - frontiersin.org
Infection with the SARS-CoV-2 virus causes cardiopulmonary and vascular complications,
ranging in severity. Understanding the pathogenic mechanisms of the novel SARS-CoV2 …

Role of dietary supplements and probiotics in modulating microbiota and bone health: the gut-bone axis

A de Sire, R de Sire, C Curci, F Castiglione, W Wahli - Cells, 2022 - mdpi.com
Osteoporosis is characterized by an alteration of bone microstructure with a decreased bone
mineral density, leading to the incidence of fragility fractures. Around 200 million people are …

Structural characterization and anti-osteoporosis effects of polysaccharide purified from Eucommia ulmoides Oliver cortex based on its modulation on bone …

J Song, Y Zhang, Y Zhu, X Jin, L Li, C Wang… - Carbohydrate …, 2023 - Elsevier
EuOCP3, with a molecular weight of 38.1 kDa, is an acidic polysaccharide purified from
Eucommia ulmoides Oliver cortex. Herein, we determined that the main backbone of …

Pathogenic mechanisms of glucocorticoid-induced osteoporosis

M Chen, W Fu, H Xu, C Liu - Cytokine & growth factor reviews, 2023 - Elsevier
Glucocorticoid (GC) is one of the most prescribed medicines to treat various inflammatory
and autoimmune diseases. However, high doses and long-term use of GCs lead to multiple …

Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis

JA Rusch, BT Layden, LR Dugas - Frontiers in endocrinology, 2023 - frontiersin.org
Cognitive function in humans depends on the complex and interplay between multiple body
systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which …

[HTML][HTML] Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function

YW Zhang, MM Cao, YJ Li, PP Lu, GC Dai… - Journal of orthopaedic …, 2022 - Elsevier
Background Osteoporosis (OP) is a systemic metabolic bone disease characterized by
decreased bone mass and destruction of bone microstructure, which tends to result in …

Prevention and treatment of glucocorticoid-induced osteoporosis in adults: consensus recommendations from the Belgian bone club

MR Laurent, S Goemaere, C Verroken… - Frontiers in …, 2022 - frontiersin.org
Glucocorticoids are effective immunomodulatory drugs used for many inflammatory
disorders as well as in transplant recipients. However, both iatrogenic and endogenous …

[HTML][HTML] COVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms

CR Settanni, G Ianiro, FR Ponziani… - World journal of …, 2021 - ncbi.nlm.nih.gov
In December 2019 a novel coronavirus disease 2019 (COVID-19), caused by the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), started spreading from Wuhan city …