Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Developing strategies toward safe and effective drug delivery into the central nervous
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …

Gene vectors are nucleic acids that carry genetic materials or gene editing devices into cells
to exert the sustained production of therapeutic proteins or to correct erroneous genes of the …

Gene therapy promises to revolutionize biomedicine and personalized medicine by
modulating or compensating the expression of abnormal genes. The biggest obstacle for …

Gene editing-based therapeutic strategies grant the power to override cell machinery and
alter faulty genes contributing to disease development like cancer. Nowadays, the principal …

Neuroinflammation is a key contributor to the pathology of Alzheimer's disease (AD). CD33
(Siglec-3) is a transmembrane sialic acid-binding receptor on the surface of microglial cells …

As extracellular vesicles secreted by cells, exosomes are intercellular signalosomes for cell
communication and pharmacological effectors. Because of their special properties, including …

Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in
neuroscience research studies for interrogating cellular and neurocircuit functions and …

Recombinant adeno-associated viral vectors (AAVs) are an effective system for gene
transfer. AAV serotype 2 (AAV2) is commonly used to deliver transgenes to retinal ganglion …

Adeno-associated viral vectors are widely used as vehicles for gene transfer to the nervous
system. The promoter and viral vector serotype are two key factors that determine the …