Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

In a society where women often want successful careers and equal opportunities to men, the
early nature of ovarian aging often forces women to make difficult life choices between …

Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Aging can not only shorten a healthy lifespan, but can also lead to multi-organ dysfunction
and failure. Anti-aging is a complex and worldwide conundrum for eliminating the various …

Decline in biological resilience (ability to recover) is a key manifestation of aging that
contributes to increase in vulnerability to death with age eventually limiting longevity even in …

Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-
inhibitory properties. Preclinical studies have shown that rapamycin extends lifespan and …

COVID-19 disproportionately affects older people, with likelihood of severe complications
and death mirroring that of other age-associated diseases. Inhibition of the mechanistic …

Ovarian reserve is a term used to estimate the total number of immature follicles present in
the ovaries. Between birth and menopause, there is a progressive decrease in the number …

Ovarian aging occurs prior to the aging of other organ systems and acts as the pacemaker of
the aging process of multiple organs. As life expectancy has increased, preventing ovarian …