Abstract Purpose of Review This review summarizes the alterations in the β-cell observed in
type 2 diabetes (T2D), focusing on changes in β-cell identity and mass and changes …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …

Down syndrome is the main cause of intellectual disabilities with a large set of comorbidities
from developmental origins but also that appeared across life span. Investigation of the …

DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications
for embryonic development, especially in the nervous system where it regulates the balance …

If assessed by a number of criteria for cancer predisposition, Down's syndrome (DS) should
be an overwhelmingly cancer-prone condition. Although childhood leukaemias occur more …

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) constitute an
evolutionarily conserved family of protein kinases with key roles in the control of cell …

People with Down syndrome have unique characteristics as a result of the presence of an
extra chromosome 21. Regarding cancer, they present a unique pattern of tumors, which …

A sufficient supply molecular oxygen is essential for the maintenance of physiologic
metabolism and bioenergetic homeostasis for most metazoans. For this reason …

Repressor element-1 silencing transcription factor (REST) or also known as neuron-
restrictive silencing factor (NRSF), is the key initiator of epigenetic neuronal gene …