Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP
inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi …

Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

Colorectal cancer (CRC) is one the greatest contributors to cancer related mortality.
Although 5 year survival rate for patients at the early stage of CRC (stages I and II) is above …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

The International Commission on Radiation Units and Measurements (ICRU), since its
inception in 1925, has had as its principal objective the development of internationally …

Synthetic lethality provides a potential mechanistic framework for the therapeutic targeting of
genetic and functional deficiencies in cancers and is now being explored widely. The first …

Recent work in human glioblastoma (GBM) has documented recurrent mutations in the
histone chaperone protein ATRX. We developed an animal model of ATRX-deficient GBM …

Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as
microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers …

Mutant RAS has remained recalcitrant to targeted therapy efforts. We demonstrate that
combined treatment with poly (adenosine diphosphate–ribose) polymerase (PARP) …