The development and widespread use of vaccines against infectious agents have been a
great triumph of medical science. One reason for the success of currently available vaccines …

Given the vast number of genetic and epigenetic changes associated with carcinogenesis, it
is clear that tumors express many neoantigens. A central question in cancer immunology is …

Despite many years of research, human DNA vaccines have yet to fulfill their early promise.
Over the past 15 years, multiple generations of DNA vaccines have been developed and …

Until recently, immunotherapies have been of limited success, particularly against cancer.
However, recent insights into the cells, molecules and signalling pathways that regulate …

B cells recognize Ag through their surface IgRs and present it in the context of MHC class II
molecules to CD4+ T cells. Recent evidence indicates that B cells also present exogenous …

Over the past few years, major advances in several areas of immunology have provided a
foundation for the rational design of vaccines against diseases requiring cellular immunity …

DNA vaccination, or genetic immunization, is a novel vaccine technology that has great
potential for reducing infectious disease and cancer-induced morbidity and mortality …

Histone deacetylase inhibitors (HDACIs) have been used to focus on the effects of inducing
gene expression through the acetylation of histones which results in chromatin remodeling …

This review focuses on DNA vaccines, denoting the last two decades since the early
substantiation of preclinical protection was published in Science in 1993 by Ulmer et al. In …

DNA vaccines have been widely used in laboratory animals and non-human primates over
the last decade to induce antibody and cellular immune responses. This approach has …