[HTML][HTML] Re-recognition of pseudogenes: From molecular to clinical applications

X Chen, L Wan, W Wang, WJ Xi, AG Yang, T Wang - Theranostics, 2020 - ncbi.nlm.nih.gov
Pseudogenes were initially regarded as “nonfunctional” genomic elements that did not have
protein-coding abilities due to several endogenous inactivating mutations. Although …

Pseudogenes as biomarkers and therapeutic targets in human cancers

C Sisu - Pseudogenes: Functions and Protocols, 2021 - Springer
Pseudogenes are commonly labeled as “junk DNA” given their perceived nonfunctional
status. However, the advent of large-scale genomics projects prompted a revisit of …

[HTML][HTML] Overexpressed pseudogenes, DUXAP8 and DUXAP9, promote growth of renal cell carcinoma and serve as unfavorable prognostic biomarkers

J Chen, W Lou, B Ding, X Wang - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
Background: Growing studies have reported that pseudogenes play key roles in multiple
human cancers. However, expression and roles of pseudogenes in renal cell carcinoma …

Pseudogene Transcripts in Head and Neck Cancer: Literature Review and In Silico Analysis

J Carron, R Della Coletta, GJ Lourenço - Genes, 2021 - mdpi.com
Once considered nonfunctional, pseudogene transcripts are now known to provide valuable
information for cancer susceptibility, including head and neck cancer (HNC), a serious …

The hsa-miR-3613–5p, a potential oncogene correlated with diagnostic and prognostic merits in kidney renal clear cell carcinoma

M Ahmadi, P Najari-Hanjani, R Ghaffarnia… - … -Research and Practice, 2023 - Elsevier
Abstract MicroRNA-3613 (hsa-miR-3613–5p), a biomarker with a dual role as an oncogenic
or tumor suppressor, is associated with different types of cancer. This study aimed to …

Whole genome sequencing of Malaysian colorectal cancer patients reveals specific druggable somatic mutations

RI Mohd Yunos, NS Ab Mutalib, J Khoo… - Frontiers in Molecular …, 2023 - frontiersin.org
The incidences of colorectal cancer (CRC) are continuously increasing in some areas of the
world, including Malaysia. In this study, we aimed to characterize the landscape of somatic …

A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis

YJ Huang, TC Lee, YC Pai, BR Lin, JR Turner… - …, 2021 - academic.oup.com
Myosin light chain kinase (MLCK) regulates actinomyosin contraction. Two splice variants of
long MLCK are expressed in epithelial cells and divergently regulate gut barrier functions; …

[HTML][HTML] Pseudogene: Relevant or Irrelevant?

YH Lin, CT Yeh, CY Chen, KH Lin - Biomedical Journal, 2024 - Elsevier
With the advancement of high-throughput technologies, the pivotal role of non-coding RNA
(ncRNA) as a master regulator of various biological functions has become increasingly …

Impact of Chondroitin Sulfate Proteoglycan 4 Pseudogene 12 Genetic Variants on Colorectal Cancer Risk: A Case-Control Study

X Zhou, L Guo, Z Yang, H Xu, Z Zhang… - DNA and Cell …, 2024 - liebertpub.com
This study aims to investigate the correlation between the chondroitin sulfate proteoglycan 4
pseudogene 12 (CSPG4P12) polymorphism and the risk of colorectal cancer (CRC). This …

The noncoding RNAs regulating pyroptosis in colon adenocarcinoma were derived from the construction of a ceRNA network and used to develop a prognostic model

Y Chen, Z Tian, H Hou, W Gai - BMC Medical Genomics, 2022 - Springer
Abstract Background Noncoding RNAs (ncRNAs), pyroptosis and tumours are all hot topics
in current research, but there are very limited studies on pyroptosis and its regulated …