The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …

Vaccines play a vital role in protecting the host against infectious disease. The most effective
licensed vaccines elicit long-term antigen-specific antibody responses by plasma cells in …

Development of improved approaches for HIV-1 prevention will likely be required for a
durable end to the global AIDS pandemic. Recent advances in preclinical studies and early …

Recent findings have brought optimism that development of a successful human
immunodeficiency virus type-1 (HIV-1) vaccine lies within reach. Studies of early events in …

We recently developed a novel strategy to identify transmitted HIV-1 genomes in acutely
infected humans using single-genome amplification and a model of random virus evolution …

For acute self-limiting infections a vaccine is successful if it elicits memory at least as good
as the natural experience; however, for persistent and chronic infections such as HIV …

Developing a human immunodeficiency virus (HIV) vaccine is critical to end the global
acquired immunodeficiency syndrome (AIDS) epidemic, but many question whether this …

The development of a safe, effective and globally affordable HIV vaccine offers the best
hope for the future control of the HIV-1 pandemic. Since 1987, scores of candidate HIV-1 …

We have shown that following priming with replicating adenovirus type 5 host range mutant
(Ad5hr)-human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) …

The quest for a prophylactic AIDS vaccine is ongoing, but it is now clear that the successful
vaccine must elicit protective antibody responses. Accordingly, intense efforts are underway …