Biological effects of human exposure to environmental cadmium

M Peana, A Pelucelli, CT Chasapis, SP Perlepes… - Biomolecules, 2022 - mdpi.com
Cadmium (Cd) is a toxic metal for the human organism and for all ecosystems. Cd is
naturally found at low levels; however, higher amounts of Cd in the environment result from …

The physiological response of photosynthesis to nitrogen deficiency

X Mu, Y Chen - Plant Physiology and Biochemistry, 2021 - Elsevier
Nitrogen (N), as a macro-element, plays a vital role in plant growth and development. N
deficiency affects plant productivity by decreasing photosynthesis, leaf area and longevity of …

The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets

D Szklarczyk, AL Gable, KC Nastou, D Lyon… - Nucleic acids …, 2021 - academic.oup.com
Cellular life depends on a complex web of functional associations between biomolecules.
Among these associations, protein–protein interactions are particularly important due to their …

The protein expression profile of ACE2 in human tissues

F Hikmet, L Méar, Å Edvinsson, P Micke… - Molecular systems …, 2020 - embopress.org
The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and
society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific …

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

D Szklarczyk, AL Gable, D Lyon, A Junge… - Nucleic acids …, 2019 - academic.oup.com
Proteins and their functional interactions form the backbone of the cellular machinery. Their
connectivity network needs to be considered for the full understanding of biological …

[HTML][HTML] Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors

T Johansen, T Lamark - Journal of molecular biology, 2020 - Elsevier
Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

[HTML][HTML] Fundamental behaviors emerge from simulations of a living minimal cell

ZR Thornburg, DM Bianchi, TA Brier, BR Gilbert… - Cell, 2022 - cell.com
We present a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell
with a reduced genome of 493 genes that has retained few regulatory proteins or small …

Ribosome biogenesis in cancer: new players and therapeutic avenues

J Pelletier, G Thomas, S Volarević - Nature Reviews Cancer, 2018 - nature.com
The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …

2016 update of the PRIDE database and its related tools

JA Vizcaíno, A Csordas, N Del-Toro… - Nucleic acids …, 2016 - academic.oup.com
Abstract The PRoteomics IDEntifications (PRIDE) database is one of the world-leading data
repositories of mass spectrometry (MS)-based proteomics data. Since the beginning of …

The functional landscape of the human phosphoproteome

D Ochoa, AF Jarnuczak, C Viéitez, M Gehre… - Nature …, 2020 - nature.com
Protein phosphorylation is a key post-translational modification regulating protein function in
almost all cellular processes. Although tens of thousands of phosphorylation sites have …