TNF is a key proinflammatory and immunoregulatory cytokine whose deregulation is
associated with the development of autoimmune diseases and other pathologies. Recent …

Type I interferonopathies cover a phenotypically heterogeneous group of rare genetic
diseases including the recently described proteasome-associated autoinflammatory …

Background In the recently published meta-analysis of multiple sclerosis genome-wide
association studies De Jager et al. identified three single nucleotide polymorphisms …

ADAM17 is a membrane-associated metalloprotease that cleaves proteins from the surface
of neutrophils and modulates the density of various receptors and adhesion molecules. The …

Objective To analyze the prevalence of diagnosed and suspected autoinflammatory
diseases in Eastern and Central European (ECE) countries, with a particular interest on the …

Autoinflammatory diseases are characterized by bouts of systemic or localized inflammation
in the absence of an infection. While some autoinflammatory diseases are caused by a …

Hereditary fever syndromes (HFS) include a group of disorders characterized by recurrent
self-limited episodes of fever accompanied by inflammatory manifestations occurring in the …

Primary immunodeficiencies (PIDs) are a heterogeneous group of rare diseases that result
from defects in immune system development and/or function. The clinical manifestations of …

Tumor necrosis factor-alpha (TNF-α) is a three monomeric glycoprotein structure composed
of 212 aminoacids, which is mainly synthesized by monocytes and macrophages. It has a …

Tumor necrosis factor-associated periodic syndrome is an autoinflammatory disorder
classified under hereditary periodic fever syndromes. Mutations in the tumor necrosis factor …