Genome folding through loop extrusion by SMC complexes
IF Davidson, JM Peters - Nature reviews Molecular cell biology, 2021 - nature.com
Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …
serve important structural and regulatory roles. It has been proposed that these genomic …
Magnesium is a key player in neuronal maturation and neuropathology
R Yamanaka, Y Shindo, K Oka - International journal of molecular …, 2019 - mdpi.com
Magnesium (Mg) is the second most abundant cation in mammalian cells, and it is essential
for numerous cellular processes including enzymatic reactions, ion channel functions …
for numerous cellular processes including enzymatic reactions, ion channel functions …
Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …
membraneless compartmentalization of the nucleus. Because chromatin compaction and …
A circadian clock regulates efflux by the blood-brain barrier in mice and human cells
SL Zhang, NF Lahens, Z Yue, DM Arnold… - Nature …, 2021 - nature.com
The blood-brain barrier (BBB) is critical for neural function. We report here circadian
regulation of the BBB in mammals. Efflux of xenobiotics by the BBB oscillates in mice, with …
regulation of the BBB in mammals. Efflux of xenobiotics by the BBB oscillates in mice, with …
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …
Single nucleosome imaging reveals loose genome chromatin networks via active RNA polymerase II
Although chromatin organization and dynamics play a critical role in gene transcription, how
they interplay remains unclear. To approach this issue, we investigated genome-wide …
they interplay remains unclear. To approach this issue, we investigated genome-wide …
Dynamic chromatin organization without the 30-nm fiber
K Maeshima, S Ide, M Babokhov - Current opinion in cell biology, 2019 - Elsevier
Chromatin in eukaryotic cells is a negatively charged polymer composed of DNA, histones,
and various associated proteins. Over the past ten years, our view of chromatin has shifted …
and various associated proteins. Over the past ten years, our view of chromatin has shifted …
Nucleolus: a central hub for nuclear functions
The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …
far from being comprehensively understood. Much work on the nucleolus has focused on its …
The solid and liquid states of chromatin
The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …
followed by a comprehensive section on phase separation of chromatin, in which we recount …
1, 6-hexanediol rapidly immobilizes and condenses chromatin in living human cells
Liquid droplets formed inside the cell by liquid–liquid phase separation maintain membrane-
less condensates/bodies (or compartments). These droplets are important for concentrating …
less condensates/bodies (or compartments). These droplets are important for concentrating …